Division of Life Science
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Angela Ruohao WU

PhD Stanford University
Assistant Professor

Email: angelawu@ust.hk

Division of Life Science, HKUST

Research Interests

My goals are to help bridge gaps between biology and engineering. To do so, my group’s research focus has two major directions: 1) investigating disease mechanisms using novel approaches such as single cell transcriptomics and gene editing; 2) development of new technologies and tools to address experimental challenges in life science research.

Representative Publications

  1. Wu, A. R. & Quake, S. R. (2015) Microfluidics Technologies for Low Cell Number Chromatin Immunoprecipitation. Cold Spring Harbor Protocols, Advance Publication doi:10.1101/pdb.prot084996
  2. Padovan-Merhar, O., Nair G., Biaesch A., Scarfone S., Foley S., Wu, A. R., Singh A., Raj A. (2015), Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Molecular Cell, 58(2), 339-352.
  3. Treutlein, B.*, Brownfield, D. G.*, Wu, A. R., Neff, N. F., Mantalas, G. L., Espinoza, F. H., Desai, T. J., Krasnow, M. A. & Quake, S. R. (2014). Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature, 509(7500), 371-375.
  4. Wu, A. R., Neff, N. F., Kalisky, T., Dalerba, P., Treutlein, B., Rothenberg, M. E., Mburu, F. M., Mantalas, G. L., Sim, S., Clarke, M. F. & Quake, S. R. (2014). Quantitative assess-ment of single-cell RNA-sequencing methods. Nature methods, 11(1), 41-46.
  5. Wu, A. R., Kawahara, T. L., Rapicavoli, N. A., van Riggelen, J., Shroff, E. H., Xu, L., Felsher, D. W., Chang, H. Y., & Quake, S. R. (2012). High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation. Lab on a chip, 12(12), 2190-2198. (Selected as one of the top 10% of all Lab on a Chip articles published in 2012)
  6. Kawahara, T. L., Rapicavoli, N. A.*, Wu, A. R.*, Qu, K., Quake, S. R., & Chang, H. Y. (2011). Dynamic chromatin localization of Sirt6 shapes stress-and aging-related transcriptional networks. PLoS genetics, 7(6), e1002153.
  7. Wu, A. R., Hiatt, J. B., Lu, R., Attema, J. L., Lobo, N. A., Weissman, I. L., Clarke, M. F. & Quake, S. R. (2009). Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab on a Chip, 9(10), 1365-1370.
  8. Lau, A. Y., Hung, P. J., Wu, A. R., & Lee, L. P. (2006). Open-access microfluidic patch-clamp array with raised lateral cell trapping sites. Lab on a Chip, 6(12), 1510-1515. (Selected as cover article)