Division of Life Science
 
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Chun LIANG

PhD Brown
Associate Professor
Associate Director, Center for Cancer Research

Email: bccliang@ust.hk

 

Research Interests
Mechanism and cell cycle control of DNA replication in the budding yeast Saccharomyces cerevisiae; regulation of DNA replication in normal and cancer cells; molecular cancer detection and anticancer drugs.

Representative Publications

  1. Yu R., Liu, H., Yu, Y., Liang L., Xu R., *Liang, C., *Tang J., and *Yao X. (2016) Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics. J. Fitoterapia (in press).
     
  2. Huang Y, Amin A., Qin Y., Wang Z., Jiang H., Liang L., Shi L., *Liang C. (2016) A Role of hIPI3 in DNA Replication Licensing in Human Cells. Plos One (in press).
     
  3. Zhang X., Xiao, D., Wang, Z., Zou, Y., Huang L., Lin, W., Deng, Q., Pan H., Zhou J., *Liang, C. and He, J.* (2014) MicroRNA-26a/b Regulate DNA Replication Licensing, Tumorigenesis and Prognosis by Targeting CDC6 in Lung Cancer. Mol. Cancer Res. 12, 1535-1546.
     
  4. Zhao C., *Lee K.Y., Xu R., Liang C., Liu D., Ma S., Wibool P., and Zohar Y. (2014) Isolation of circulating tumor cells under hydrodynamic loading using microfluidic technology. Advances Mechanics, 44, 447-494.
     
  5. Huo L., R. Wu, Z. Yu, Y. Zhai, X. Yang, T. Chan, J. Yeung, J. Kan, and *Liang C. (2012) The Rix1 (Ipi1p-2p-3p) Complex Is a Critical Determinant of DNA Replication Licensing Independent of Their Roles in Ribosome Biogenesis. Cell Cycle 11, 1325-1339.
     
  6. Liu, C., Wu, R., Wei, Z., Wang, J., Tye, B., *Liang, C., and *Zhu G. (2012) Structural Insights into the Cdt1-Mediated Mcm2-7 Chromatin Loading. Nucleic Acids Res. 40, 3208-3217 (*co-corresponding authors).
     
  7. Wu, R., Wang, J., and *Liang, C. (2012) Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. J. Cell Sci. 125, 209-219.
     
  8. Geng, H., Law, P., Ng, M., Li, T., Liang, L., Ge, T., Wong, K., Liang, C., Ma, R., So, W., Chan, J., *Ho, Y. (2011) APOE Genotype-Function Relationship: Evidence of 2491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk. PLoS ONE 6, e24669-e24669.
     
  9. Lai, F.Q., Wu, R.T. Wang, J.F., Li, C.M., Zou, L., Lu Y.J., and *Liang, C. (2011) Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. FEMS Yeast Res. 11, 72-79.
     
  10. Zhai, Y., Yung, P., and *Liang. C. (2011) Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast. Chapter 6 in “Fundamental Aspects of DNA Replication”. InTech Publisher; Ed. J. Kušić-Tišma; pp87-106.
     
  11. Zhai, Y.L. Yung, P., Huo L. and *Liang C. (2010) Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins. J. Cell Sci. 123, 3933-3943.
     
  12. Cheng, X., Xu, Z., Wang, J.F., Zhai, Y.L, Lu, Y.J, and *Liang, C. (2010) ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast. J. Biol. Chem. 285, 29974-29980.
     
  13. Zhang J., Yu, L., Wu., X., Zou., L. Sou, K.K.L, Wei, Z., Cheng X., *Zhu, G.. and *Liang C. (2010) The Interacting Domains of hCdt1 and hMcm6 Involved in the Chromatin Loading of the MCM Complex in Human Cells. Cell Cycle 9, 4848-4857 (*co-corresponding authors)
     
  14. Wei, Z., Liu, C.D., Xu, N.N., Wu, X. Zhou, B., *Liang, C., and *Zhu, G. (2010) Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J. Boil. Chem. 285, 12469-12473 (accelerated publication) (*co-corresponding authors).
     
  15. Ma, L.J., Zhai, Y.L., Feng, D.R., Chan, T.C., Lu, J.L., Fu, X.R., Wang, J.F., Chen, Y.H., Li, J.N., Xu, K. and *Liang, C. (2010) Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen in Saccharomyces cerevisiae. Cell Cycle 9, 4399-4410.
     
  16. Wang, J.F., Wu, R.T., Lu, Y.J. and *Liang, C. (2010) Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast. Biochem. Biophys. Res. Commun. 395, 336-341.
     
  17. Xiong X.D., Qiu F.E., Fang J.H., Shen Y., Liang C., Jiang W., and *Zhuang S.M. (2009) Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. Mutat. Res. 662: 10-15.
     
  18. Li, J.N, Feng, C. J.,, Lu, Y.J., Li, H.J., Tu, Z., Liao, G.Q., and *Liang, C. (2008) mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue. BMC Cancer 8: 395-412.
     
  19. Kan J, Zou L, Zhang J, Wu R, Wang Z, and *Liang C. (2008) Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae. J. Biol. Chem. 283, 33803-33807 (accelerated publication).
     
  20. Wu ,W.B., Liang, H.Q., Kan, J.S., Liu, C., Yuan, M.J., Liang, C., *Yang, K. and *Pang, Y. (2008) Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80 and Itself. J. Virol. 82:12356-12364.
     
  21. Foulk, M.S., Liang, C., Wu, N., Blitzblau, H.G., Smith, H., Alam, D., Batra, M. and *Gerbi, S.A. (2006) Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A. Dev Biol. 299: 151-163.
     
  22. Yu, Z.L., Feng, D.R. and *Liang, C. (2004) Pairwise Interactions of the Six Human MCM Protein Subunits. J. Mol. Biol. 340: 1197-1206.
     
  23. Feng, D.R., Tu Z., Wu, W.Y., and *Liang, C. (2003) Inhibiting the Expression of DNA Replication-Initiation Proteins Induces Apoptosis in Human Cancer Cells. Cancer Res. 63: 7356-7364.
     
  24. Fu, X.R., Ng, C., Feng, D.R., and *Liang C. (2003) Cdc48p Is Required for the Cell Cycle Commitment Point at START via Degradation of the G1-CDK Inhibitor Far1p. J. Cell Biol. 163: 21-26.
     
  25. Zhang, Y.X., Yu, Z.L., Fu, X.R., and *Liang, C. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell, 109, 849-860.
     
  26. Urnov, F.D., Liang, C., Blitzblau, H.G., Smith, H.S. & *Gerbi, S.A. (2002) A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara. Chromosoma 111, 291-303.
     
  27. Weinreich, M., Liang, C., Chen, H. H., and *Stillman, B. (2001) Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proc. Natl. Acad. Sci., USA. 98, 11211-11217.
     
  28. Weinreich, M. Liang, C., and *Stillman, B. (1999) The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin. Proc. Natl. Acad. Sci., USA, 96: 441-446.
     
  29. *Gerbi, S.A., Bielinsky, A., Liang, C., Lunyak, V. and Urnov, F. (1999) Methods to map origins of replication in eukaryotes. In "Eukaryotic DNA Replication: A Practical Approach". Ed. S. Cotterill. Oxford University Press. Chapter 1, pp 1-42.
     
  30. Liang, C. and *Stillman, B. (1997) Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev., 11: 3375-3386.
     
  31. Liang, C., Weinreich, M. and *Stillman, B. (1995) ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell, 81: 667-676.
     
  32. Liang, C. and *Gerbi, S.A. (1994) Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method. Mol. Cell. Biol. 14: 1520-1529.
     
  33. Liang, C., Spitzer, J.D., Smith, H.S. and *Gerbi, S.A. (1993) Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A. Genes Dev. 7: 1072-1084.
     
  34. *Gerbi, S.A., Liang, C., Wu, N., DiBartolomeis, S., Bienz-Tadmor, B., Smith, H.S. and Urnov, F.D. (1993) DNA amplification in DNA puff II/9A of Sciara coprophila. Quant. Biol. 58: 487-494.
     
  35. Wu, N.#, Liang, C.#, Smith, H.S.#, DiBartolomeis#, S.M. and *Gerbi, S.A. (1993) Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription. Dev. Biol. 160: 73-84. (#, equal contribution).
     
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