Associate Professor Associate Director, Center for Cancer Research Email: bccliang@ust.hk

Representative Publications

1. Huo L., R. Wu, Z. Yu, Y. Zhai, X. Yang, T. Chan, J. Yeung, J. Kan, and *Liang C. (2012) The Rix1 (Ipi1p-2p-3p) Complex Is a Critical Determinant of DNA Replication Licensing Independent of Their Roles in Ribosome Biogenesis. Cell Cycle 11, 1325-1339.
 

2. Liu, C., Wu, R., Wei, Z., Wang, J., Tye, B., *Liang, C., and *Zhu G. (2012) Structural Insights into the Cdt1-Mediated Mcm2-7 Chromatin Loading. Nucleic Acids Res. 40, 3208-3217 (*co-corresponding authors).
 

3. Wu, R., Wang, J., and Liang, C. (2012) Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. J. Cell Sci. 125, 209-219.
 

4. Geng, H., Law, P., Ng, M., Li, T., Liang, L., Ge, T., Wong, K., Liang, C., Ma, R., So, W., Chan, J., Ho, Y. (2011) APOE Genotype-Function Relationship: Evidence of 2491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk. PLoS ONE 6, e24669-e24669.
 

5. Zhai, Y., Yung, P., and Liang. C. (2011) Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast. Chapter 6 in “Fundamental Aspects of DNA Replication”. InTech Publisher; Ed. J. Kušić-Tišma; pp87-106.
 

6. Lai, F.Q., Wu, R.T. Wang, J.F., Li, C.M., Zou, L., Lu Y.J., and Liang, C. (2011) Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. FEMS Yeast Res. 11, 72-79.
 

7. Zhang J., Yu, L., Wu., X., Zou., L. Sou, K.K.L, Wei, Z., Cheng X., Zhu, G.*. and Liang C.* (2010) The Interacting Domains of hCdt1 and hMcm6 Involved in the Chromatin Loading of the MCM Complex in Human Cells. Cell Cycle 9, 4848-4857 (*co-corresponding authors)
 

8. Ma, L.J., Zhai, Y.L., Feng, D.R., Chan, T.C., Lu, J.L., Fu, X.R., Wang, J.F., Chen, Y.H., Li, J.N., Xu, K. and Liang, C. (2010) Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen in Saccharomyces cerevisiae. Cell Cycle 9, 4399-4410.
 

9. Zhai, Y.L. Yung, P., Huo L. and Liang C. (2010) Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins.  J. Cell Sci. 123, 3933-3943.
 

10. Cheng, X., Xu, Z., Wang, J.F., Zhai, Y.L, Lu, Y.J, and Liang, C. (2010) ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast.. J. Biol. Chem. 285, 29974-29980.
 

11. Wei, Z., Liu, C.D., Xu, N.N., Wu, X. Zhou, B., Liang, C.*, and Zhu, G.* （2010）Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J. Boil. Chem. 285, 12469-12473 (accelerated publication) (*co-corresponding authors).
 

12. Wang, J.F., Wu, R.T., Lu, Y.J. and Liang, C. (2010) Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast. Biochem. Biophys. Res. Commun. 395, 336-341.
 

13. Xiong X.D., Qiu F.E., Fang J.H., Shen Y., Liang C., Jiang W., and Zhuang S.M. (2009) Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. Mutat. Res. 662: 10-15.
 

14. Li, J.N, Feng, C. J.,, Lu, Y.J., Li, H.J., Tu, Z., Liao, G.Q., and Liang, C. (2008) mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue. BMC Cancer 8: 395-412.
 

15. Kan J, Zou L, Zhang J, Wu R, Wang Z, and Liang C. (2008) Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae. J. Biol. Chem. 283, 33803-33807 (accelerated publication).
 

16. Wu ,W.B., Liang,  H.Q., Kan, J.S., Liu, C., Yuan, M.J., Liang, C., Yang, K. and Pang, Y. (2008) Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80 and Itself. J. Virol. 82:12356-12364.
 

17. Foulk, M.S., Liang, C., Wu, N., Blitzblau, H.G., Smith, H., Alam, D., Batra, M. and Gerbi, S.A. (2006) Ecdysone induces transcription and amplification in Sciara coprophila DNA puff II/9A. Dev Biol. 299: 151-163.
 

18. Yu, Z.L., Feng, D.R. and Liang, C. (2004) Pairwise Interactions of the Six Human MCM Protein Subunits. J. Mol. Biol. 340: 1197-1206.
 

19.  Feng, D.R., Tu Z., Wu, W.Y., and Liang, C. (2003) Inhibiting the Expression of DNA Replication-Initiation Proteins Induces Apoptosis in Human Cancer Cells. Cancer Res. 63: 7356-7364.
 

20. Fu, X.R., Ng, C., Feng, D.R., and Liang C. (2003) Cdc48p Is Required for the Cell Cycle Commitment Point at START via Degradation of the G1-CDK Inhibitor Far1p. J. Cell Biol. 163: 21-26.
 

21. Zhang, Y.X., Yu, Z.L., Fu, X.R., and Liang, C. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell, 109, 849-860.
 

22. Urnov, F.D., Liang, C., Blitzblau, H.G., Smith, H.S. & Gerbi, S.A. (2002) A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara. Chromosoma 111, 291-303.
 

23. Liang, C. (2001) Initiation proteins for DNA replication in normal and cancer cells. In "Molecular Genetic Basis of Cancer", ed. M.L. Lung and W.L.W. Hsiao. Published by HKUST, pp316-324.
 

24. Weinreich, M., Liang, C., Chen, H. H., and Stillman, B. (2001) Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proc. Natl. Acad. Sci., USA. 98, 11211-11217.
 

25. Weinreich, M. Liang, C., and Stillman, B. (1999) The Cdc6p nucleotide binding motif is required for loading Mcm proteins onto chromatin. Proc. Natl. Acad. Sci., USA, 96: 441-446.
 

26. Gerbi, S.A., Bielinsky, A., Liang, C., Lunyak, V. and Urnov, F. (1999) Methods to map origins of replication in eukaryotes.  In "Eukaryotic DNA Replication: A Practical Approach".  Ed. S. Cotterill. Oxford University Press. Chapter 1, pp 1-42.
 

27. Liang, C. and Stillman, B. (1997) Persistent initiation of DNA replication and chromatin bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev., 11: 3375-3386.
 

28. Liang, C., Weinreich, M. and Stillman, B. (1995) ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell, 81: 667-676.
 

29. Liang, C. and Gerbi, S.A. (1994) Analysis of an origin of DNA amplification in Sciara coprophila using a novel three-dimensional gel method. Mol. Cell. Biol. 14: 1520-1529.
 

30. Liang, C., Spitzer, J.D., Smith, H.S. and Gerbi, S.A. (1993) Replication initiates at a confined region during DNA amplification in Sciara DNA puff II/9A. Genes Dev. 7: 1072-1084.
 

31. Gerbi, S.A., Liang, C., Wu, N., DiBartolomeis, S., Bienz-Tadmor, B., Smith, H.S. and Urnov, F.D. (1993) DNA amplification in DNA puff II/9A of Sciara coprophila. Quant. Biol. 58: 487-494.
 

32. Wu, N.^#, Liang, C.^#, Smith, H.S.^#, DiBartolomeis^#, S.M. and Gerbi, S.A. (1993) Developmental progression in Sciara coprophila DNA puffs: DNA amplification and transcription. Dev. Biol. 160: 73-84. (#, equal contribution).

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