Division of Life Science
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Kenny K. CHUNG

PhD Cambridge
Associate Professor

Email: bckchung@ust.hk

Research Interests
Molecular mechanisms of Neurodegeneration. Functional studies of genes that are linked to familial Parkinson’s disease.

Representative Publications

  1. Wan, O.W. and Chung, K.K. (2012). The role of alpha-synuclein aggregation in the pathogenesis of Parkinson’s disease. PLoS ONE. 7:e38545
  2. Xie, W. and Chung, K.K. (2012). Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease. J. Neurochem. 122:404-414
  3. Li, Y., Wan, O.W., Xie, W. and Chung, K.K. (2011). p32 regulates mitochondrial morphology and dynamics through parkin. Neuroscience. 199:346-58.
  4. Zhang, P., Yu, P., Tsang, A. H., Chen, Y., Fu, A.K., Fu, W.Y., Chung, K.K. and Ip, N.Y. (2010). S-nitrosylation of Cdk5 regulates the kinase activity and dendrite growth during neuronal development. J. Neurosci. 30:14366.
  5. Xie, W., Wan, O.W. and Chung, K.K. (2010). New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease. Biochim Biophys Acta. 1802: 935-941.
  6. Chung, K.K. (2010). Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration. Apoptosis. 11:1364-70.
  7. Chung, K.K. and David, K.K. (2010). Emerging roles of nitric oxide in neurodegeneration. Nitric Oxide: Biology and Chemistry. 22: 290-5.
  8. Tsang, A.H. and Chung, K.K. (2009). Oxidative stress and nitrosative stress in Parkinson’s disease. Biochim Biophys Acta. 1792: 643-650.
  9. Lee, F.K.M., Wong, A.K.Y., Lee, Y.W., Wan, O. W., Chan, H.Y.E. & Chung, K.K. (2009). The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson’s disease. J. Neurochem. 110: 208-219.
  10. Tsang, A.H., Lee, Y.I., Ko, H.S., Savitt, J. M., Pletnikova, O. Troncoso, J.C., Dawson, V.L., Dawson, T.M. and Chung, K.K. (2009). S-Nitrosylation of XIAP compromises neuronal survival in Parkinson’s disease. Proc Natl Acad Sci U S A. 106: 4900-5.
  11. Chung, K.K. (2007). Say NO to neurodegeneration: the role of S-nitrosylation in neurodegenerative disorders. NeuroSignals. 15: 307-13.
  12. Chung, K. K., Dawson, T. M. & Dawson, V. L. (2005). Nitric oxide, S-nitrosylation and neurodegeneration. Cell. Mol. Biol. 51: 247-54.
  13. Chung, K. K., Dawson, V. L. & Dawson, T. M. (2005). S-Nitrosylation in Parkinson’s Disease and related neurodegenerative disorders. Meth. Enzymol. 396: 139-50.
  14. Ko, H.S., von Coelln, R., Sriram, S.R., Kim, S.W., Chung, K.K., Pletnikova, O., Troncoso, J., Johnson, B., Saffary, R., Goh, E.L., Song, H., Park, B.J., Kim, M.J., Kim, S., Dawson, V.L. and Dawson, T.M. (2005) Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neurosci. 25: 7968-78.
  15. Sriram, S.R., Li, X., Ko, H.S., Chung, K.K., Wong, E., Lim, K.L., Dawson, V.L. and Dawson, T.M. (2005). Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Hum. Mol. Genet. 14: 2571-86.
  16. Lim, K.L., Chew, K.C.M., Tan, J.M.M., Wang, C., Chung, K.K., Zhang, Y., Tanaka, Y., Wei, W.L., Engelender, S., Ross, C.A., Dawson, V.L. and Dawson, T.M. (2005). Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation. J. Neurosci. 25: 2002-9.
  17. Chung, K. K., & Dawson, T. M. (2004). Parkin and HSP70 sacked by BAG5. Neuron 44: 899-901.
  18. Chung, K. K., Thomas, B., Li, X., Pletnikova, O., Troncoso, J. C., Marsh, L., Dawson, V. L. & Dawson, T. M. (2004). S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function. Science 304(5675): 1328-31.
  19. Chung, K. K., Dawson, V. L. & Dawson, T. M. (2003). New insights into Parkinson’s disease. J Neurol 250 Suppl 3: III15-24.
  20. Choi, P., Snyder, H., Petrucelli, L., Theisler, C., Chong, M., Zhang, Y., Lim, K., Chung, K. K., Kehoe, K., D’Adamio, L., Lee, J. M., Cochran, E., Bowser, R., Dawson, T. M. & Wolozin, B. (2003). SEPT5_v2 is a parkin-binding protein. Brain Res Mol Brain Res 117(2): 179-89.
  21. Chung, K.K., Zhang, Y., Lim, K.L., Tanaka, Y., Huang, H., Gao, J., Ross, C., Dawson, V.L. & Dawson, T.M. (2001). Parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson’s disease. Nature Med. 7, 10: 1144-1150.
  22. Chung, K.K., Dawson, V.L. & Dawson, T.M. (2001). The role of the ubiquitin proteasomal pathway in Parkinson’s Disease and other neurodegenerative disorders. TINS. 24, 11: S7-S14.
  23. Zhang, Y. Gao, J. Chung, K.K., Huang, H., Dawson, V.L. & Dawson, T.M. (2000). Parkin functions as an E3-dependent ubiquitin-protein ligase and promotes the degradation of synaptic vesicle associated protein, CDCrel-1. Proc .Natl. Acad. Sci. USA, 97, 24: 13354-9.

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