Associate Professor Email: bohuangp@ust.hk

The research in my lab focuses on the regulation of epithelial ion channels including CFTR, by chemical and mechanical cues. In addition, my lab is interested in other related questions in epithelial biology and molecular mechanobiology.

Representative Publications

1. Zhang WK*, Wang, D*, Duan Y, Loy MMT, Chan HC, Huang P. Mechanosensitive gating of CFTR. Nature Cell Biology, 12(5): 507-12, 2010, (*equal contributions)
    
2. Luo J, Li W, Zhao Y, Fu H, Ma DL, Tang J, Li C, Peoples RW, Li F, Wang Q, Huang P, Xia J, Pang Y, Han Y. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer Bis(propyl)-cognitin. J Biol Chem, 285(26):19947-58, 2010
    
3. Chen, MH, Chen H, Zhou Z, Ruan YC, Wong HY, Lu YC, Guo JH, Chung YW, Huang PB, Huang HF, Zhou WL, Chan HC. Involvement of CFTR in oviductal HCO3- secretion and its effect on soluble adenylate cyclase-dependent early embryo development. Human Reproduction, in press, 2010
    
4. Wang D, Sun Y, Zhang W, and Huang P. Apical adenosine regulates basolateral Ca++-activated potassium channels in human airway Calu-3 epithelial cells. American Journal of Physiology (Cell Physiology) 294: C1443-1453, 2008
    
5. Wang D, Wang W, Duan Y, Sun Y, Wang Y, and Huang P. Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells. Pflugers Arch-European Journal of Physiology 456: 929-938, 2008.
    
6. Sun Y, Wu F, Sun F, and Huang P. Adenosine promotes IL-6 release in airway epithelia. Journal of Immunology 180, 4173-4181, 2008
    
7. Gao J, Zhang W, Huang P, Zhang B, Zhang X, and Xu B. Spatial control of flurorescent magnetic nanoparticles inside cells. Journal of the American Chemical Society 130 (12), 370-1, 2008
    
8. Mi Y, Chan Y, Trau D, Huang P, and Chen E. Micromolding of PDMS scaffolds and microwells for tissue culture and cell patterning: A new method of microfabrication by the self-assembled micropatterns of diblock copolymer micelles. Polymer 47:5124-5130, 2006
    
9. Wang Y, Lam CK, Wu F, Wang W, Duan Y, and Huang P. Regulation of CFTR channels by bicarbonate-sensitive soluble adenylyl cyclase in human airway epithelial cells. Am J Physiol Cell Physiol 289:C1145-C1151, 2005.
    
10. Barnes AP*, Livera G*, Huang P*, Sun C, O'Neal W K, Conti M, Stutts MJ, and Milgram SL. Phosphodiesterase 4D Forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem 280 (9), 7997-8003, 2005, (*equal contributions).
     
11. Okada SF, O'Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER, and Boucher RC. Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol 124: 513-526, 2004.
     
12. Huang P, Gilmore E, Kultgen P, Barnes P, Migram SL, and Stutts MJ. Local regulation of cystic fibrosis transmembrane regulator and epithelial sodium channel in airway epithelium. Proc Am Thorac Sco 1: 33-37, 2004
     
13. Huang P, Lazarowski ER, Tarran R, Milgram SL, Boucher RC, and Stutts MJ. Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proc Natl Acad Sci U S A 98: 14120-14125, 2001, (featured in the cover, and the commentary of No.25 issue).

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