Division of Life Science
 
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Robert Z. QI
PhD Calgary
Associate Professor

Email: qirz@ust.hk

 
Research Interests
The current research focuses on understanding the molecular mechanisms that regulate microtubule cytoskeletal organization during cell division, migration, and differentiation, and how defects in these mechanisms result in diseases such as cancer and neurodegenerative diseases. The laboratory’s work applies biochemical, mass spectrometric, molecular and cell biology methods to the study of these fundamental questions in cell biology.

Representative Publications

  1. L. He*, Z. Zhang*, Y. Yu, S. Ahmed, N.S. Cheung, and R.Z. Qi (2011). The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein, Cell. Mol. Life Sci., 68(9), 1633-1643. (*Equal contribution)
     
  2. Choi, Y.-K., Liu, P., Sze, S.K., Dai, C., and Qi, R.Z. (2010). CDK5RAP2 stimulates microtubule nucleation by the -tubulin ring complex, J. Cell Biol., 191(6), 1089-1095.
     
  3. Wang, Z., Wu, T., Shi, L., Zhang, L., Zheng, W., Qu, J.Y., Niu, R., and Qi, R.Z. (2010). Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex, J. Biol. Chem., 285(29), 22658-22665.
     
  4. Fong, K.W., Hau, S.Y., Kho, Y.S., Jia, Y., He, L., and Qi, R.Z. (2009). Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics, Mol. Biol. Cell. 20(16), 3660-3670.
     
  5. He, L., Hou, Z., and Qi, R.Z. (2008). Calmodulin-binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules. J. Biol. Chem. 283(19), 13252-13260.
     
  6. Fong, K.-W., Choi, Y.-W., Rattner, J.B., and Qi, R.Z. (2008). CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the γ-tubulin ring complex. Mol. Biol. Cell 19(1), 115-125.
     
  7. Hou, Z., Li, Q., He, L., Lim, H.-Y., Fu, X., Cheung, N.S., Qi, D.X., and Qi, R.Z. (2007). Microtubule association of the neuronal p35 activator of Cdk5. J. Biol. Chem. 282(26), 18666-18670.
     
  8. Hou, Z., He, L., and Qi, R.Z. (2007). Regulation of S6 kinase 1 activation by phosphorylation at Ser411. J. Biol. Chem. 282(10), 6922-6928.
     
  9. Fu, X., Choi, Y.-K., Qu, D., Yu, Y., Cheung, N.S., and Qi, R.Z. (2006). Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J. Biol. Chem. 281(51), 39014-39021.
     
  10. Lim, A.C.B., Hou, Z., Goh, C.-P., and Qi, R.Z. (2004). Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase. J. Biol. Chem. 279(45), 46668-46673.
     
  11. Song, Y., Kesuma, D., Wang, J., Deng, Y., Duan, J., Wang, J.H., and Qi, R.Z. (2004). Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem. Biophys. Res. Commun. 317(1), 128-132.
     
  12. Lim, A.C.B., Tiu, S.-Y., Li, Q., and Qi, R.Z. (2004). Direct regulation of microtubule dynamics by protein kinase CK2. J. Biol. Chem. 279(6), 4433-4439.
     
  13. Lim, A.C.B., Qu, D., and Qi, R.Z. (2003). Protein-protein interactions in Cdk5 regulation and function. Neurosignals 12(4-5), 230-238.
     
  14. Lim, A.C.B., and Qi, R.Z. (2003). Cyclin-dependent kinases in neural development and degeneration. J. Alzheimer’s Dis. 5(4), 329-335.
     
  15. Qu, D., Li, Q., Lim, H.-Y., Cheung, N.S., Li, R., Wang, J.H., and Qi, R.Z. (2002). Protein SET binds neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. J. Biol. Chem. 277(9), 7324-7332.

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