Division of Life Science
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Tom Hiu Tung CHEUNG

PhD University of Colorado at Boulder
Assistant Professor

Email: tcheung@ust.hk

Laboratory website: cheunglab.ust.hk


Research Interests

Molecular mechanisms of stem cell quiescence and activation

Adult stem cells have the unique ability to produce differentiated daughter cells as well as replenish the stem pool through the process of self-renewal. In the absence of stimulus, subsets of mammalian adult stem cells can reside in the quiescent state for prolonged periods of time. Importantly, disruption of quiescence was shown to result in the depletion of the stem cell pool. Satellite cells are adult muscle stem cells that are primarily quiescent in resting muscle and that represent an excellent model to study stem cell quiescence. The main areas of interest of the laboratory are to specify the molecular pathways that control stem cell quiescence and stem cell-mediated tissue regeneration. Using both in vitro and in vivo approaches, we are also interested in getting a better understanding of adult stem cell function in the context of tissue regeneration, disease and aging.


Representative Publications

  1. Liu L, Cheung TH, Charville GW and Rando TA. Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting. Nature Protocols. 2015. Oct;10(10):1612-24.
  2. Charville GW, Cheung TH, Yoo B, Santos P, Lee GK, Shrager JB and Rando TA. Ex vivo expansion and in vivo self-renewal of human muscle stem cells. Stem Cell Reports. 2015. Oct 13;5(4):621-32.
  3. Liu L, Cheung TH, Charville GW, Hurgo BM, Leavitt T, Shih J, Brunet A, Rando TA. (2013) Chromatin Modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Reports. 2013 Jun 27. doi:pii: S2211-1247(13)00276-3. 10.1016/j.celrep.2013.05.043.
  4. Cheung TH, Rando TA. (2013) Molecular regulation of stem cell quiescence. Nature Reviews Molecular Cell Biology. 2013 Jun;14(6):329-40. doi: 10.1038/nrm3591.
  5. Mueller AA, Cheung TH, Rando TA. (2013). All's well that ends well: alternative polyadenylation and its implications for stem cell biology. Current Opinion in Cell Biology. 2013 Apr;25(2):222-32. doi: 10.1016/j.ceb.2012.12.008.
  6. Boutet SC*, Cheung TH*, Quach NL*, Liu L, Prescott SL, Edalati A, Iori K, Rando TA. (2012). Alternative polyadenylation mediates microRNA regulation of muscle stem cell function. Cell Stem Cell. 2012 Mar 2;10(3):327-36. doi: 10.1016/j.stem.2012.01.017. (*authors contributed equally to the study)
  7. Cheung TH, Quach NL, Charville GW, Liu L, Park L, Edalati A, Yoo B, Hoang P, Rando TA. (2012). Maintenance of muscle stem-cell quiescence by microRNA-489. Nature. 2012 Feb 23;482(7386):524-8. doi: 10.1038/nature10834.
  8. Bjornson CR, Cheung TH, Liu L, Tripathi PV, Steeper KM, Rando TA. (2012). Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells. 2012 Feb;30(2):232-42. doi: 10.1002/stem.773.
  9. Luczak ED, Barthel KKB, Stauffer BL, Konhilas JP, Cheung TH and Leinwand LA. (2011). Remodeling the cardiac transcriptional landscape with diet. Physiological Genomics. 2011 Jun 28;43(12):772-80.
  10.  Zhang L, Ding L, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates J and Han M. (2007). Systematic identification of miRISC proteins, miRNAs, and their mRNA targets in C. elegans by their interactions with GW182 family proteins AIN-1 and AIN-2. Molecular Cell. 2007 Nov 30;28(4):598-613.
  11. Cheung TH*, Barthel KKB*, Kwan YL, Liu X. (2007). Putative regulatory islands conserved in mammalian genomes. Proceedings of the National Academy of Sciences. 2007 Jun 12;104(24):10116-21. (*authors contributed equally to the study)
  12. Cheung TH, Kwan YL, Hamady M, Liu X. (2006). Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT. Genome Biology. 2006;7(10):R97.
  13. Schweppe RE, Cheung TH, Ahn NG. (2006). Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses. Journal of Biological Chemistry. 2006 Jul 28;281(30):20993-1003.
  14. Knuesel M, Cheung TH, Hamady M, Barthel K, Liu X. (2005). A method of mapping protein sumoylation site by mass spectrometry using a modified SUMO and a computational program. Molecular and Cellular Proteomics. 2005 Oct;4(10):1626-36.
  15. Hamady M, Cheung T, Tufo H, Knight R. (2005). Using structural properties to predict behavior of related proteins: Does protein structure influence trypsin miscleavage? IEEE Eng Med Biol Mag. 2005 May-Jun;24(3):58-66.
  16. Hamady M, Cheung T, Resing K, Krzysztof C, Knight R. (2005). Key challenges in proteomics and proteoinformatics. IEEE Eng Med Biol Mag. 2005 May-Jun;24(3):34-40.
  17. Resing KA, Meyer-Arendt K, Mendoza AM, Aveline-Wolf LD, Jonscher KR, Pierce KG, Old WM, Cheung HT, Russell S, Wattawa JL, Goehle GR, Knight RD, Ahn NG. (2004). Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics. Analytical Chemistry, 2004 Jul 1;76(13):3556-68.
  18. Macdonald M, Wan Y, Wang W, Roberts E, Cheung TH, Erickson R, Knuesel MT, Liu X. (2004). Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34. Oncogene. 2004 Jul 22;23(33):5643-53.

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