Division of Life Science
 
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Tom Hiu Tung CHEUNG

PhD University of Colorado at Boulder
S H Ho Assistant Professor of Life Science

Email: tcheung@ust.hk

Laboratory website: cheunglab.ust.hk

 

Research Interests
 

Molecular mechanisms of stem cell quiescence and activation

Adult stem cells have the unique ability to produce differentiated daughter cells as well as replenish the stem pool through the process of self-renewal. In the absence of stimulus, subsets of mammalian adult stem cells can reside in the quiescent state for prolonged periods of time. Importantly, disruption of quiescence was shown to result in the depletion of the stem cell pool. Satellite cells are adult muscle stem cells that are primarily quiescent in resting muscle and that represent an excellent model to study stem cell quiescence. The main areas of interest of the laboratory are to specify the molecular pathways that control stem cell quiescence and stem cell-mediated tissue regeneration. Using both in vitro and in vivo approaches, we are also interested in getting a better understanding of adult stem cell function in the context of tissue regeneration, disease and aging.

 

Representative Publications (Full List)

  1. Mueller AA, van Velthoven CT, Fukumoto KD, Cheung TH and Rando TA. Intronic Polyadenylation of PDGFRa in resident stem cells attenuates muscle fibrosis. Nature. 2016 Nov 28. doi: 10.1038/nature20160.
     
  2. Zhu H, Xiao F, Wang G, Wei X, Jiang L, Chen Y, Zhu L, Wang H, Diao Y, Wang H, Ip NY, Cheung TH, Wu Z. STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. Cell Reports. 2016 Aug 10. pii: S2211-1247(16)30959-7.
     
  3. Liu L, Cheung TH, Charville GW and Rando TA. Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting. Nature Protocols. 2015. Oct;10(10):1612-24.
     
  4. Charville GW, Cheung TH, Yoo B, Santos P, Lee GK, Shrager JB and Rando TA. Ex vivo expansion and in vivo self-renewal of human muscle stem cells. Stem Cell Reports. 2015. Oct 13;5(4):621-32.
     
  5. Liu L, Cheung TH, Charville GW, Hurgo BM, Leavitt T, Shih J, Brunet A, Rando TA. (2013) Chromatin Modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Reports. 2013 Jun 27. doi:pii: S2211-1247(13)00276-3. 10.1016/j.celrep.2013.05.043.
     
  6. Cheung TH, Rando TA. (2013) Molecular regulation of stem cell quiescence. Nature Reviews Molecular Cell Biology. 2013 Jun;14(6):329-40. doi: 10.1038/nrm3591.
     
  7. Mueller AA, Cheung TH, Rando TA. (2013). All's well that ends well: alternative polyadenylation and its implications for stem cell biology. Current Opinion in Cell Biology. 2013 Apr;25(2):222-32. doi: 10.1016/j.ceb.2012.12.008.
     
  8. Boutet SC*, Cheung TH*, Quach NL*, Liu L, Prescott SL, Edalati A, Iori K, Rando TA. (2012). Alternative polyadenylation mediates microRNA regulation of muscle stem cell function. Cell Stem Cell. 2012 Mar 2;10(3):327-36. doi: 10.1016/j.stem.2012.01.017. (*authors contributed equally to the study)
     
  9. Cheung TH, Quach NL, Charville GW, Liu L, Park L, Edalati A, Yoo B, Hoang P, Rando TA. (2012). Maintenance of muscle stem-cell quiescence by microRNA-489. Nature. 2012 Feb 23;482(7386):524-8. doi: 10.1038/nature10834.
     
  10. Bjornson CR, Cheung TH, Liu L, Tripathi PV, Steeper KM, Rando TA. (2012). Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells. 2012 Feb;30(2):232-42. doi: 10.1002/stem.773.
     

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