Division of Life Science
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Hong XUE

PhD Toronto

Email: hxue@ust.hk

Research Interests
My group research focuses on genomics, bioinformatics and evolution biology to decipher the mechanisms of human complex disorders. The group is also interested in translational research on novel therapeutics and diagnostics for complex diseases such as neuropsychiatric disorders.

Representative Publications

  1. Cunyou Zhao and Hong Xue (2012) A simple method for high-throughput quantification of genome-wide DNA methylation by fluorescence polarization. Epigenetics 7:335-339
  2. Cunyou Zhao, Feng Wang, Frank W. Pun, Lingling Mei, Lihuan Ren, Zhiliang Yu, Siu-Kin Ng, Jianhuan Chen, Shui-Ying Tsang and Hong Xue (2012) Epigenetic regulations on GABRB2 isoform expressions: developmental variations and disruptions in psychotic disorders. Schizophrenia Research 134:260-266
  3. Lingling Mei, Xiaofan Ding, Shui-Ying Tsang, Frank W. Pun, Siu-Kin Ng, Cunyou Zhao, Dezhi Li, Weiqing Wan, Gilberto Ka Kit Leung, Ho-Keung Ng, Liwei Zhang and Hong Xue (2011) AluScan: a method for genome-wide scanning of sequence variations in the human genome. BMC Genomics 12:564
  4. Can Yang, Xiaowei Zhou, Xiang Wan, Qiang Yang, Hong Xue and Weichuan Yu (2011) Identifying disease-associated SNP clusters via contiguous outlier detection. Bioinformatics 27:2578-85
  5. Lihuan Ren, Wing Man Chan, Feng Wang, Zhiwen Xu, Cunyou Zhao, Wai Kin Mat, Yanwen Chai, J. Tze-Fei Wong, Shui Ying Tsang and Hong Xue (2011) Effects of flavonoid 6-substitutions on GABAA receptors efficacy. European Journal of Pharmacology 670:121-129
  6. Frank W. Pun, Cunyou Zhao, Wing-Sze Lo, Siu-Kin Ng, Vishwajit Nimgaonkar, W.S. Chung, G.S. Ungvari, Shui-Ying Tsang and Hong Xue (2010) Imprinting in the schizophrenia candidate gene GABRB2 encoding GABAA receptor β2 subunit. Molecular Psychiatry 16: 557-568
  7. Wai-kin Mat, Hong Xue and J. Tze-Fei Wong (2010) Genetic code mutations: the breaking of a three billion year invariance. PLoS ONE 5(8):e12206
  8. Xiang Wan, Can Yang, Qiang Yang, Hong Xue, Nelson L.S. Tang and Weichuan Yu (2010) BOOST: a fast approach to detecting gene-gene interactions in genome-wide case-control studies. American Journal of Human Genetics 87:325-340
  9. Songfa Zhong, Salomon Israel, Idan Shalev, Hong Xue, Richard P. Ebstein, and Soo Hong Chew (2010) Dopamine D4 receptor gene associated with fairness preference in ultimatum game. PLoS ONE 5(11):e13765
  10. The International Cancer Genome Consortium (2010) International network of cancer genome projects. Nature 464(7291):993-998
  11. Siu-Kin Ng, Wing-Sze Lo, Frank W. Pun, Cunyou Zhao, Zhiliang Yu, Jianhuan Chen, Ka-Lok Tong, Zhiwen Xu, Shui-Ying Tsang, Qiang Yang, Weichuan Yu, Vishwajit Nimgaonkar, Gerald Stöber, Mutsuo Harano, and Hong Xue (2010) A recombination hotspot in a schizophrenia-associated region of GABRB2. PLoS ONE 5(3): e9547
  12. Qi Liu, Qian Xu, Vincent W. Zheng, Hong Xue, Zhiwei Cao and Qiang Yang (2010) Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study. BMC Bioinformatics 11:181 (http://www.biomedcentral.com/1471-2105/11/181)
  13. Xiang Wan, Can Yang, Qiang Yang, Hong Xue, Nelson L.S. Tang and Weichuan Yu (2010) Detecting two-locus associations allowing for interactions in genome-wide association studies. Bioinformatics 26(20):2517-2525
  14. Ren, Lihuan, Feng Wang, Zhiwen Xu, Wing Man Chan, Cunyou Zhao and Hong Xue (2010) GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochemical Pharmacology 79 (9):1337-1344
  15. Xu, Qian; Pan, Sinno Jialin; Xue, Hannah Hong; Yang, Qiang (2010) Multitask Learning for Protein Subcellular Location Prediction. IEEE/ACM Transactions on Computational Biology and Bioinformatics 8(3):748-759
  16. Songfa Zhong, Salomon Israel, Hong Xue, Richard P. Ebstein, and Soo Hong Chew (2010) Monoamine Oxidase A Gene (MAOA) associated with Attitude towards Longshot Risks. PLoS ONE. 4(12):e8516
  17. Xiang Wan, Can Yang, Qiang Yang, Hong Xue and Weichuan Yu (2010) Predictive rule inference for epistatic interaction detection in genome-wide association studies. Bioinformatics 26(1):30-37
  18. Qian Xu, Hong Xue and Qiang Yang (2010) Multi-Platform Gene Expression Mining and Marker Gene Analysis. International Journal of Data Mining and Bioinformatics (Interscience) (In press)
  19. Zhiliang Yu, Ken Takai, Alexei Slesarev, Hong Xue, J. Tze-Fei Wong (2009) Search for Primitive Methanopyrus Based on Genetic Distance Between Val- and Ile-tRNA Synthetases. J. Mol. Evol. 69: 386-394
  20. Zhao, CY, Zhiwen Xu, Feng Wang, Jianhuan Chen, Siu-Kin Ng, Pak-Wing Wong, Zhiliang Yu, Frank W. Pun, Lihuan Ren, Wing-Sze Lo, Shui-Ying Tsang and Hong Xue (2009) Alternative-splicing in the Exon-10 region of GABAA receptor β2 subunit gene: relationships between novel isoforms and psychotic disorders. PLoS ONE 4(9): e6977
  21. Songfa Zhong, Salomon Israel, Hong Xue, Pak C. Sham, Richard P. Ebstein, and Soo Hong Chew (2009) A Neurochemical Approach to Valuation Sensitivity over Gains and Losses. Proceedings of the Royal Society B: Biological Sciences. 276(1676):4181-4188
  22. Qian Xu, Hong Xue, Weichuan Yu, Hong Yan and Qiang Yang (2009) Cross-Platform Gene Expression Data Analysis using Multi-task Learning. BMC bioinformatics 10 Suppl 1:S47
  23. Songfa Zhong, Soo Hong Chew, Eric Set, Junsen Zhang, Hong Xue, Pak C. Sham, Richard P. Ebstein, and Salomon Israel (2009) The heritability of attitude towards economic risk. Twin Research and Human Genetics 12: 103-107
  24. Can Yang, Wan, Xiang, Qiang Yang, Hong Xue, Nelson Tang and Weichuan Yu (2009) SNPHarvester: a filtering-based approach for detecting epistatic interactions in genome-wide association studies. Bioinformatics 25: 504-511
  25. Xu, Qian, Derek Hao Hu, Hong Xue and Qiang Yang (2009) Semi-supervised Protein Subcellular Localization. BMC Bioinformatics 10 (Suppl. 1): S47
  26. Xiang Wan, Can Yang, Qiang Yang, Hong Xue, Nelson L.S. Tang and Weichuan Yu (2009) MegaSNPHunter: a learning approach to detect disease predisposition SNPs and high level interactions in genome wide association study. BMC Bioinformatics 10:13
  27. Wang, Feng, Zhiwen Xu, Lihuan Ren, Shui Ying Tsang and Hong Xue (2008) GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin. Neuropharmacology 55:1231-1237
  28. Mak, Wai-Kin, Hong Xue and Jeffrey Tze-Fei Wong (2008) The genomics of LUCA. Frontiers in Bioscience 13, 5605-5613
  29. The International HapMap Consortium (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861
  30. Pardis Sabeti et al. and the International HapMap Consortium (2007) Genome-wide detection and characterization of positive selection in human populations. Nature 449, 913-919
  31. Wong, J. Tze-Fei, Jianhuan Chen, Wai-Kin Mat, Siu-Kin Ng and H. Xue (2007) Polyphasic evidence for the delineation of the root of life and roots of biological domains. Gene 403:39-52
  32. Feng Wang, Zhiwen Xu, Chun Tak Yuen, Chui Yin Chow, Yuk Long Lui, Shui Ying Tsang, and Hong Xue (2007) 6, 2'-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine site. Neuropharmacology 53:574-582
  33. Guo, Li-Tao; Chen, Xiang-Long; Zhao, Bo-Tao; Shi, Yi; Li, Wei; Xue, Hong; Jin, Youxin (2007) Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. Nucleic Acid Research 35:5934-5943
  34. Wing-Sze Lo, Zhiwen Xu, Zhiliang Yu, Frank W. Pun, Siu-Kin Ng, Jianhuan Chen, Ka-Lok Tong, Cunyou Zhao, Xiaojing Xu, Shui-Ying Tsang, Mutsuo Harano, Gerald Stöber, Vishwajit L. Nimgaonkar and Hong Xue (2007) Positive selection within the schizophrenia-associated GABAA receptor β2 gene. PLoS ONE 2(5): e462. doi:10.1371/journal.pone.0000462
  35. Shui-Ying Tsang, Siu-Kin Ng, Zhiwen Xu and Hong Xue (2007) The evolution of GABAA receptor-like genes. Molecular Biology and Evolution 24:599-610
  36. Wing-Sze Lo, Mutsuo Harano, Micha Gawlik, Zhiliang Yu, Jianhuan Chen, Frank Wing Pun, Ka-Lok Tong, Cunyou Zhao, Siu-Kin Ng, Shui-Ying Tsang, Naohisa Uchimura, Gerald Stoeber and Hong Xue (2007) GABRB2 association with schizophrenia: commonalities and differences between ethnic groups and clinical subtypes. Biological Psychiatry 61:653-660
  37. Cunyou Zhao, Zhiwen Xu, Jianhuan Chen, Zhiliang Yu, Ka-Lok Tong, Wing Sze, Cario Lo, Frank Wing Pun, Siu-Kin Ng, Shui-Ying Tsang, and Hong Xue (2006) Two isoforms of GABAA receptor β2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia. Molecular Psychiatry 11:1092-1105
  38. Xiang-Long Chen, Bing Huang, Li-Tao Guo, Hong Xue, You-Xin Jin (2006) Mutant Human Tryptophanyl-tRNA Synthetase Capable of Esterifying but Not Activating Tryptophan. Biochemical Journal (In press)
  39. Zhiliang Yu, Jianhuan Chen, Haifeng Shi, Gerald Stoeber, Shui Ying Tsang and Hong Xue (2006) Association of SNPs in GABRB2 with schizophrenia in German population: application of two-base extension genotyping. Clinical Biochemistry 39 (3): 210-218
  40. Zhiwen Xu, Feng Wang, Shui Ying Tsang, Kwan Hang Ho, Hui Zheng, Chun Tak Yuen, Chun Yin Chow and Hong Xue (2006) Anxiolytic-like effect of baicalin and its additivity with other anxiolytics. Planta Medica 72: 189-192
  41. Siu-Kin Ng and Hong Xue (2006) Alu-Associated Enhancement of Single Nucleotide Polymorphisms in the Human Genome. Gene 368: 110-116
  42. Zhiwen Xu, Hui Zheng, Sek Lun Law, Donna Dong So, Yifan Han and Hong Xue (2006) Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. J. Peptide Sci. 12: 72-78
  43. The International HapMap Consortium (2005) A Haplotype Map of the Human Genome. Nature 437:1299-1320
  44. Zhiwen Xu, Shisong Fang, Haifeng Shi, Hoiming Li, Jiun-Ming Wu, Hueih-Min Chen, Yiqun Deng, Yinglei Liao, Hui Zheng, Huaimin Zhu, Shui Ying Tsang and Hong Xue (2005) Topology characterization of a benzodiazepine-binding b-rich domain of the GABAA receptor a1 subunit. Protein Science 14: 2622 – 2637
  45. Xue, Hong, Siu-Kin Ng, Kalok Tong, J. Tze-fei Wong (2005) Congruence of evdence for a Methanopyrus-proximal root of life based on tRNA and aminoacyl-tRNA synthetase genes. Gene 360:120-130
  46. Wenming Li, Rongbiao Pi, Hugh H. N. Chan, Hongjun Fu, Nelson T. K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Chaoying Li, Jialie Luo, Keming Xiong, Zhiwang Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W. K. Tsim, Mingtao Li, and Yifan Han (2005) Novel dimeric AChE inhibitor Bis(7)-tacrine, but not Donepezil, prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. J. Biol. Chem. 280: 18179-18188
  47. Wing-Sze Lo, Ching-Fun Lau, Zhenyu Xuan, Anthony Chun-Fung Chan, Guo-Yin Feng, Lin He, Zhong-Chang Cao, Hua Liu, Qing-Ming Luan, and Hong Xue (2004) Association of SNPs and haplotypes in GABAA receptor b2 gene with schizophrenia. Molecular Psychiatry 9(6): 603-608 (advance online publication 16 December 2003; doi:10.1038/sj.mp.4001461)
  48. Haifeng Shi, Shui Ying Tsang, Man Kit Tse, Zhiwen Xu and Hong Xue (2003) Recombinant extracellular domain of the three major subunits of GABAA receptor show comparable secondary structure and benzodiazepine binding properties. Protein Sci. 12(11):2642-2546
  49. Michael S.Y. Huen, Hong Yan Wang, Kwok Min Hui, Justin W.C. Leung, Erwin Sigel, Roland Baur, J. Tze Fei Wong and Hong Xue (2003) Naturally occurring 2’hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochemical Pharmacology 66:2397-2407
  50. Xue, Hong, Ka-Lok Tong, Christian Marck, Henri Grosjean and J. Tze-Fei Wong (2003) Transfer RNA paralogs: evidence for genetic code-amino acid biosynthesis coevolution and an archaeal root of life. Gene 310: 59-66
  51. Wai Chung Leung, Michael Huen, Sek Lun Law, Hui Zheng, Hong Xue (2003) Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27 (56): 775-779
  52. Wanqing Liu, Gerome Breen, Jiangang Zhang, Sheng Li, Niufan Gu, Guoyin Feng, Shaochun Bai, Tao Shen, Albert Yu, Hong Xue, David St. Clair, Lin He (2003) Association of APOE gene with schizophrenia in Chinese: a possible risk factor in times of malnutrition. Schizophrenia Research 62:225-230
  53. Michael S.Y. Huen, Justin W.C. Leung, Wah Ng, W.S. Lui, Michelle N.S. Chan, J. Tze-Fei Wong and Hong Xue (2003) 5,7-dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochemical Pharmacology. 66: 125-132
  54. Wang H, Hui KM, Xu S, Chen Y, Wong JT, Xue H (2002) Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex. Pharmazie 57(12):857-858
  55. Hongyan Wang, Kwok-Min Hui, Yingjie Chen, Suixu Xu, J. Tze-Fei Wong, Hong Xue (2002) Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABAA receptor complex. Planta Med 68: 1059-1062
  56. Haifeng Shi, Shui Ying Tsang, Hui Zheng, James N. Sturgis and Hong Xue (2002) Two b-rich structural domains in GABAA receptor  a1  subunit with different physical properties: evidence for multi-domain nature of the receptor. Protein Sci. 11 (8): 2052-2058
  57. Qingguo Gong, Qing Guo, Ka-Lok Tong, Guang Zhu, J. Tze-Fei Wong and Hong Xue (2002) NMR Analysis of bovine tRNATrp: conformation dependence of Mg2+ binding. J. Biol. Chem. 277 (23): 20694-20701
  58. Hui, Kwok Min, Michael S.Y. Huen, Hong Yan Wang, Hui Zheng, Erwin Sigel, Roland Baur, Hong Ren, Zhi Wang Li, J. Tze-Fei Wong and Hong Xue (2002) Anxiolyic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem. Pharmacol. 64 (9): 1415-1424
  59. Qing Guo, Qingguo Gong, Bente Vestergaard, Annie Costa, Jean Desgers, Mansim Wong, Henri Grosjean, J. Tze-Fei Wong and Hong Xue (2002) Recognition by tryptophanyl-tRNA synthetase of discriminator base on tRNATrp from three biological domains. J. Biol. Chem. 277(16):14343-14349
  60. Deng, Yi-qun, Zhen-yu Zhu, Jian-quan Ma, Hong Xue (2002) Ligand Binding and Structural Properties of The Cys166-Leu296 Segment of GABAA Receptor a1 Subunit. Chin. J. Biochem. Mol. Biol. 18 (3): 367-372
  61. Xue, Hong, Haifeng Shi, Shui Ying Tsang, Hui Zheng, Christos G. Savva, Jingchuan Sun and Andreas Holzenburg (2001) A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABAA counterpart. J. Mol. Biol. 312(5): 915-920
  62. Tian, Qiong, Shaozhang Zhang, Qin Pu, Fake Zhang and Hong Xue (2001) Effect of BMPs on heamatopoietic injury of acute radiation sickness in mice. J. Radiat. Res. Radiat. Process. 19(3):199-204 (Chinese)
  63. Huang, Xiaoqin, Tong Liu, Jiande Gu, Xiaomin Luo, Ruyun Ji, Yang Cao, Hong Xue, J. Tze-Fei Wong, Bing L. Wong, Gang Pei, Hualiang Jiang and Kaixian Chen (2001) 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. Journal of Medicinal Chemistry 44: 1883-1891
  64. Shao, Fuyuan, Liuqin Huang, Hong Xue and Yifan Han (2001) Vascular dementia. Chinese Clinical Neuroscience 9(1): 92-95 (Chinese)
  65. Huang Xiao-Qin, Jiang Hua-Liang, Luo Xiao-Min, Shen Jing-Kang, Chen Kai-Xian2, Ji Ru-Yun, Cao Yang and Hong Xue (2001) A 3D-structural model of memapsin 2 protease generated from theoretical study. Acta Pharmacologica Sinica. 22(1): 50-56 (Chinese)
  66. Jun Hang, Haifeng Shi, Dongyang Li, Yinglei Liao, Dejun Lian, Yazhong Xiao, and Hong Xue (2000) Ligand binding and structural properties of segments of GABAA receptor α1 subunit overexpressed in Escherichia coli. J. Biol. Chem. 275(25): 18818-18823
  67. Songshan Jiang, Jun Yu, Jian Wang, Zeng Tan, Hong Xue, Guoyin Feng, Lin He and Huanming Yang (2000) Complete Genomic Sequence of 195 kb of Human DNA Containing the Gene GABRG2. DNA Seq: 11(5):373-382
  68. Xue, H, H Zheng, HM Li, A Kitmitto, H Zhu, P Lee and A Holzenburg (2000) A fragment of recombinant GABAA receptor α1 subunit forming rosette-like homo-oligomers. J. Mol. Biol. 296 (3): 739-742
  69. Rachedi, A, M Rebhan and H Xue (2000) GABAagent: a database system for retrieving integrated data on GABA receptors. Bioinformatics. 16 (4): 301-312
    [3D-GDD (http://gaba.ust.hk/gdd) and GABAagent (http://gaba.ust.hk) databases have been featured under the NetWatch category in Science 287:5455 on February 11, 2000.]
  70. Yan, X, H Xue, H Liu, J Hang, JT Wong and G Zhu (2000) NMR studies of Bacillus subtilis tRNATrp hyperexpressed in Escherichia coli: Assignment of imino proton signals and determination of thermal stability. J. Biol. Chem. 275(10): 6712-6716
  71. Hui, KM, XH Wang and H Xue (2000) Interaction of flavones from the roots of Scutellaria baicalensis with benzodiazepine site. Planta Medica. 66(1): 91-93
  72. Chow, C, H Xue and JL Fu (2000) Targeted duplication of p35Nck5a gene: vector construction and ES cell gene targeting. Acta Genetica Sinica. 10 (8): 1-5 (Chinese)
  73. Chen L, YX Jin, DB Wang, M-S Wong, H Xue and JT Wong (2000) Species-specific identity elements of tRNATrp. Progress in Natural Science. 10(3): 192-197
  74. Wang, H, S Zhao, W Zhao, G Feng, W Liu, S Li, H Xue and L He (2000) Congenital absence of permanent teeth in a six-generation Chinese kindred. American J. Medical Genetics. 90(3): 193-198
  75. Chow, C, H Xue and JL Fu (2000) Construction of gene targeting vector for duplicating p35Nck5a gene and its application in the gene targeting of ES cells. Acta Genetica Sinica 27 (8): 659 - 665
  76. Chow, C, XM Dai, H Xue and JL Fu (1999) Cloning and characterization of mouse neuronal cdc2-like kinase regulatory subunit p35Nck5a gene. Acad. J. Second. Milit. Med. Univ. 20(10):716-719
  77. Liu, W, N Gu, G Feng, S Li, S Bai, J Zhang, T Shen, H Xue, G Breen, D St Clair and L He (1999) Tentative association of the serotonin transporter with Schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics. 9: 491-495
  78. Guo, Q and H Xue (1999) Studies on identity elements of transfer RNA for tryptophan. Chemistry of Life. 19(4):153-155 (Chinese)
  79. Xue, H, J Hang, R Chu, Y Xiao, H Li, P Lee, and H Zheng (1999) Delineation of a membrane-proximal β-rich domain in GABAA receptor by progressive deletions. J. Mol. Biol. 285(1):55-61
  80. Li, CY, H Xue, H Wang, PR Carlier, KM Hui, YP Pang, ZW Li and YF Han (1999) Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABAA receptor antagonist. NeuroReport. 10:795-800
  81. Xue, H (1998) Identification of major phylogenetic branches of inhibitory ligand gated channel receptors. J. Mol. Evol. 47:323-333
  82. Xue, H, RA Chu, J Hang, P Lee and H Zheng (1998) Fragment of GABAA receptor containing key ligand-binding residues overexpressed in Escherichia coli. Protein Science.7:216-219
  83. Smith, DK and H Xue (1998) A major component approach to present consensus sequences. Bioinformatics. 14:151-156
  84. Zhang, B, H Xue and B. Lin (1998) Application of capillary zone electrophoresis to the study of interaction between Bacillus subtilis tryptophanyl-tRNA synthetase and tRNATrp. Chromatographia. 48:268-272
  85. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Construction and application of gene targeting replacement vector for mouse coagulation factor IX gene. J Med Coll PLA 13:106-110
  86. Xue, H, H Zheng and XF Wu (1998) Preparation of highly purified hemoglobin by affinity elution. Art. Cells, Blood Subs. & Immob. Biotech. 26(3):317-327
  87. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Targeted disruption of coagulation factor IX gene in mouse embryonic stem cells. Acad. J. Second. Milit. Med. Univ. 19 (1): 1-4 (Chinese)
  88. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Construction and application of gene targeting replacement vector. Acad. J. Second. Milit. Med. Univ. 19 (1): 5-8 (Chinese)
  89. Dai, X, H Xue and J Fu (1998) Genomic structural analysis and targeted disruption of mouse coagulation factor IX gene in ES cells. J. Fudan Uni. (Natural Sci.) 37:577-578 (Chinese)
  90. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Separating /combining strategy for restriction mapping the large genomic insert in recombinant phage vector. Prog. Biochem. Biophys. 25(5):454-459 (Chinese)
  91. Xue, H, YL Xue, S Doublié and CW Carter (1997) Chemical modification of Bacillus subtilis tryptophanyl-tRNA synthetase. Biochem. and Cell Biol. 75:709-715
  92. Smith, DK and H Xue (1997) Sequence profiles of immunoglobulin and immunoglobulin-like domains. J. Mol. Biol. 274:530-545
  93. Dai, X, H Xue, H Yang, Y Hu and J Fu (1997) Application of PCR and genomic southern blotting to molecular identification of homologous recombination events in gene targeting. Chinese J. Med. Genet. 14(6):339-343 (Chinese)
  94. Hogue, CWV, S Doulié, H Xue, JT Wong, CW Carter and AG Szabo (1996) A concerted tryptophanyl-adenylate-dependent conformational change in Bacillus subtilis tryptophanyl-tRNA synthetase revealed by the fluorescence of Trp92. J. Mol. Biol. 260:446-466
  95. Xue, H and JT Wong (1995) Interferon induction of human tryptophanyl-tRNA synthetase safeguards the synthesis of tryptophan-rich immune system proteins: a hypothesis. Gene 165:335-339
  96. Xue, H, WY Shen, R Giege and JT Wong (1993) Identity elements of Bacillus subtilis tRNATrp: Identification and evolutionary conservation. J. Biol. Chem. 268:9316-9322
  97. Xue, H, A Glasser, J Desgress, H Grosjean (1993) Modified nucleosides in Bacillus subtilis tRNATrp hyperexpressed in Escherichia coli. Nuleic Acids Research 21:2479-2486
  98. Xue, H, WY Shen and JT Wong (1993) Purification of hyperexpressed Bacillus subtilis tRNATrp gene cloned in Escherichia coli. J. Chromatography 613:247-255
  99. Ala, P, H Xue, L Leung, YQ Xue, JT Wong and DDS Yang (1993) Purification and crystallization of tryptophanyl-tRNA synthetase. J. Mol. Biol. 230:1089-1090
  100. Xue, H and YF Zhang (1992) Pulmonary fat embolism in rabbits induced by forced immobilization. J. Trauma 32:415-419
  101. Chow, KC, H Xue, W Shi and JT Wong (1992) Mutational identification of an essential tryptophan in tryptophanyl-tRNA synthetase of Bacillus subtilis. J. Biol. Chem. 267:9146-9149
  102. Xue, H, XF Wu and JT Wong (1992) Properties of hemoglobin and dextran-hemoglobin rightshifted by oxidized inositol tetrakisphosphate. Aritificial Organs, 16:14-18


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