Professor Email: hxue@ust.hk

Representative Publications

1. Wing-Sze Lo, Zhiwen Xu, Zhiliang Yu, Frank W. Pun, Siu-Kin Ng, Jianhuan Chen, Ka-Lok Tong, Cunyou Zhao, Xiaojing Xu, Shui-Ying Tsang, Mutsuo Harano, Gerald Stober, Vishwajit L. Nimgaonkar and Hong Xue (2007) Positive selection within the schizophrenia-associated GABAA receptor b2 gene. PLoS ONE 2007 May 23; 2(5): e462.
    
2. Shui-Ying Tsang, Siu-Kin Ng, Zhiwen Xu and Hong Xue (2007) The evolution of GABAA receptor-like genes. Molecular Biology and Evolution 24: 599-610.
    
3. Wing-Sze Lo, Mutsuo Harano, Micha Gawlik, Zhiliang Yu, Jianhuan Chen, Frank Wing Pun, Ka-Lok Tong, cunyou Zhao, Siu-Kin Ng, Shui-Ying Tsang, Naohisa Uchimura, Gerald Stoeber and Hong Xue (2007) GABRB2 associated with schizophrenia: commonalities and differences between ethnic groups and clinical subtypes. Biological Psychiatry 61: 653-60.
    
4. Cunyou Zhao, Zhiwen Xu, Jianhuan Chen, Zhiliang Yu, Ka-Lok Tong, Wing Sze Cario Lo, Frank Wing Pun, Siu-Kin Ng, Shui-Ying Tsang and Hong Xue (2006) Two isoforms of GABAA receptor b2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia. Molecular Psychiatry 11: 1092-105.
    
5. Zhiliang Yu, Jianhuan Chen, Haifeng Shi, Gerald Stoeber, Shui Ying Tsang and Hong Xue (2006) Association of SNPs in GABRB2 with schizophrenia in German population: application of two-base extension genotyping. Clinical Biochemistry 39(3): 210-218.
    
6. Zhiwen Xu, Feng Wang, Shui Ying Tsang, Kwan Hang Ho, Hui Zheng, Chun Tak Yuen, Chun Yin Chow and Hong Xue (2006) Anxiolytic-like effect of baicalin and its additivity with other anxiolytics. Planta Medica 72: 189-192.
    
7. Siu-Kin Ng and Hong Xue (2006) Alu-Associated Enhancement of Single Nucleotide Polymorphisms in the Human Genome. Gene 368: 110-116.
    
8. Zhiwen Xu, Hui Zheng, Sek Lun Law, Donna Dong So, Yifan Han and Hong Xue (2006) Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. J. Peptide Sci. 12: 72-8
    
9. The International HapMap Consortium (2005) A Haplotype Map of the Human Genome. Nature 437:1299-1320
    
10. Zhiwen Xu, Shisong Fang, Haifeng Shi, Hoiming Li, Jiun-Ming Wu, Hueih-Min Chen, Yiqun Deng, Yinglei Liao, Hui Zheng, Huaimin Zhu, Shui Ying Tsang and Hong Xue (2005) Topology characterization of a benzodiazepine-binding b-rich domain of the GABAA receptor a1 subunit. Protein Science 14: 2622-2637.
     
11. Xue, Hong, Siu-Kin Ng, Kalok Tong, J. Tze-fei Wong (2005) Congruence of evdence for a Methanopyrus-proximal root of life based on tRNA and aminoacyl-tRNA synthetase genes. Gene 360:120-130
     
12. Wenming Li, Rongbiao Pi, Hugh H. N. Chan, Hongjun Fu, Nelson T. K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Chaoying Li, Jialie Luo, Keming Xiong, Zhiwang Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W. K. Tsim, Mingtao Li, and Yifan Han (2005) Novel dimeric AChE inhibitor Bis(7)-tacrine, but not Donepezil, prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. J. Biol. Chem. 280: 18179-88
     
13. Wing-Sze Lo, Ching-Fun Lau, Zhenyu Xuan, Anthony Chun-Fung Chan, Guo-Yin Feng, Lin He, Zhong-Chang Cao, Hua Liu, Qing-Ming Luan, and Hong Xue (2004) Association of SNPs and haplotypes in GABAA receptor b2 gene with schizophrenia. Molecular Psychiatry 9(6): 603-8 (advance online publication 16 December 2003 ; doi:10.1038/sj.mp.4001461)
     
14. Haifeng Shi, Shui Ying Tsang, Man Kit Tse, Zhiwen Xu and Hong Xue (2003) Recombinant extracellular domain of the three major subunits of GABAA receptor show comparable secondary structure and benzodiazepine binding properties. Protein Sci. 12(11):2642-6
     
15. Michael S.Y. Huen, Hong Yan Wang, Kwok Min Hui, Justin W.C. Leung, Erwin Sigel, Roland Baur, J. Tze Fei Wong and Hong Xue (2003) Naturally occurring 2-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochemical Pharmacology 66:2397-407
     
16. Xue, Hong, Ka-Lok Tong, Christian Marck, Henri Grosjean and J. Tze-Fei Wong (2003) Transfer RNA paralogs: evidence for genetic code-amino acid biosynthesis coevolution and an archaeal root of life. Gene 310: 59-66
     
17. Wai Chung Leung, Michael Huen, Sek Lun Law, Hui Zheng, Hong Xue (2003) Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27 (56): 775-779
     
18. Wanqing Liu, Gerome Breen, Jiangang Zhang, Sheng Li, Niufan Gu, Guoyin Feng, Shaochun Bai, Tao Shen, Albert Yu, Hong Xue, David St. Clair, Lin He (2003) Association of APOE gene with schizophrenia in Chinese: a possible risk factor in times of malnutrition. Schizophrenia Research 62:225-230
     
19. Michael S.Y. Huen, Justin W.C. Leung, Wah Ng, W.S. Lui, Michelle N.S. Chan, J. Tze-Fei Wong and Hong Xue (2003) 5,7-dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochemical Pharmacology. 66: 125-132
     
20. Wang H, Hui KM, Xu S, Chen Y, Wong JT, Xue H (2002) Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex. Pharmazie 57(12):857-8
     
21. Hongyan Wang, Kwok-Min Hui, Yingjie Chen, Suixu Xu, J. Tze-Fei Wong, Hong Xue (2002) Structure-Activity Relationships of Flavonoids, Isolated from Scutellaria baicalensis, Binding to Benzodiazepine Site of GABAA Receptor Complex. Planta Med 68: 1059-1062
     
22. Haifeng Shi, Shui Ying Tsang, Hui Zheng, James N. Sturgis and Hong Xue (2002) Two b-rich structural domains in GABAA receptor b subunit with different physical properties: evidence for multi-domain nature of the receptor. Protein Sci. 11 (8): 2052-2058
     
23. Qingguo Gong, Qing Guo, Ka-Lok Tong, Guang Zhu, J. Tze-Fei Wong and Hong Xue (2002) NMR Analysis of bovine tRNATrp: conformation dependence of Mg2+ binding. J. Biol. Chem. 277 (23): 20694-20701
     
24. Hui, Kwok Min, Michael S.Y. Huen, Hong Yan Wang, Hui Zheng, Erwin Sigel, Roland Baur, Hong Ren, Zhi Wang Li, J. Tze-Fei Wong and Hong Xue (2002) Anxiolyic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem. Pharmacol. 64 (9): 1415-1424.
     
25. Qing Guo, Qingguo Gong, Bente Vestergaard, Annie Costa, Jean Desgers, Mansim Wong, Henri Grosjean, J. Tze-Fei Wong and Hong Xue (2002) Recognition by tryptophanyl-tRNA synthetase of discriminator base on tRNATrp from three biological domains. J. Biol. Chem. 277(16):14343-14349.
     
26. Deng, Yi-qun, Zhen-yu Zhu, Jian-quan Ma, Hong Xue (2002) Ligand Binding and Structural Properties of The Cys166-Leu296 Segment of GABAA Receptor a1 Subunit. Chin. J. Biochem. Mol. Biol. 18 (3): 367-372.
     
27. Xue, Hong, Haifeng Shi, Shui Ying Tsang, Hui Zheng, Christos G. Savva, Jingchuan Sun and Andreas Holzenburg (2001) A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABAA counterpart. J. Mol. Biol. 312(5): 915-920
     
28. Tian, Qiong, Shaozhang Zhang, Qin Pu, Fake Zhang and Hong Xue (2001) Effect of BMPs on heamatopoietic injury of acute radiation sickness in mice. J. Radiat. Res. Radiat. Process. 19(3):199-204
     
29. Huang, Xiaoqin, Tong Liu, Jiande Gu, Xiaomin Luo, Ruyun Ji, Yang Cao, Hong Xue, J. Tze-Fei Wong, Bing L. Wong, Gang Pei, Hualiang Jiang and Kaixian Chen (2001) 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. Journal of Medicinal Chemistry 44: 1883-1891
     
30. Shao, Fuyuan, Liuqin Huang, Hong Xue and Yifan Han (2001) Vascular dementia. Chinese Clinical Neuroscience 9(1): 92-95 (Chinese)
     
31. Huang Xiao-Qin, Jiang Hua-Liang, Luo Xiao-Min, Shen Jing-Kang, Chen Kai-Xian2, Ji Ru-Yun, Cao Yang and Hong Xue (2001) A 3D-structural model of memapsin 2 protease generated from theoretical study. Acta Pharmacologica Sinica. 22(1): 50-56 (Chinese)
     
32. Jun Hang, Haifeng Shi, Dongyang Li, Yinglei Liao, Dejun Lian, Yazhong Xiao, and Hong Xue (2000) Ligand binding and structural properties of segments of GABAA receptor b subunit overexpressed in Escherichia coli. J. Biol. Chem. 275(25): 18818-18823
     
33. Songshan Jiang, Jun Yu, Jian Wang, Zeng Tan, Hong Xue, Guoyin Feng, Lin He and Huanming Yang (2000) Complete Genomic Sequence of 195 kb of Human DNA Containing the Gene GABRG2. DNA Seq: 11(5):373-82
     
34. Xue, H, H Zheng, HM Li, A Kitmitto, H Zhu, P Lee and A Holzenburg (2000) A fragment of recombinant GABAA receptor b subunit forming rosette-like homo-oligomers. J. Mol. Biol. 296 (3): 739-742
     
35. Rachedi, A, M Rebhan and H Xue (2000) GABAagent: a database system for retrieving integrated data on GABA receptors. Bioinformatics. 16 (4): 301-312
     
36. [3D-GDD (http://gaba.ust.hk/gdd) and GABAagent (http://gaba.ust.hk) databases have been featured under the NetWatch category in Science 287:5455 on February 11, 2000 .]
     
37. Yan, X, H Xue, H Liu, J Hang, JT Wong and G Zhu (2000) NMR studies of Bacillus subtilis tRNATrp hyperexpressed in Escherichia coli: Assignment of imino proton signals and determination of thermal stability. J. Biol. Chem. 275(10): 6712-6716
     
38. Hui, KM, XH Wang and H Xue (2000) Interaction of flavones from the roots of Scutellaria baicalensis with benzodiazepine site. Planta Medica. 66(1): 91-3
     
39. Chow, C, H Xue and JL Fu (2000) Targeted duplication of p35Nck5a gene: vector construction and ES cell gene targeting. Acta Genetica Sinica. 10 (8): 1-5 (Chinese)
     
40. Chen L, YX Jin, DB Wang, M-S Wong, H Xue and JT Wong (2000) Species-specific identity elements of tRNATrp. Progress in Natural Science. 10(3): 192-197
     
41. Wang, H, S Zhao, W Zhao, G Feng, W Liu, S Li, H Xue and L He (2000) Congenital absence of permanent teeth in a six-generation Chinese kindred. American J. Medical Genetics. 90(3): 193-8
     
42. Chow, C, H Xue and JL Fu (2000) Construction of gene targeting vector for duplicating p35Nck5a gene and its application in the gene targeting of ES cells. Acta Genetica Sinica 27 (8): 659 - 665
     
43. Chow, C, XM Dai, H Xue and JL Fu (1999) Cloning and characterization of mouse neuronal cdc2-like kinase regulatory subunit p35Nck5a gene. Acad. J. Second. Milit. Med. Univ. 20(10):716-719
     
44. Liu, W, N Gu, G Feng, S Li, S Bai, J Zhang, T Shen, H Xue, G Breen, D St Clair and L He (1999) Tentative association of the serotonin transporter with Schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics. 9: 491-495
     
45. Guo, Q and H Xue (1999) Studies on identity elements of transfer RNA for tryptophan. Chemistry of Life. 19(4):153-155 (Chinese)
     
46. Wang, Q, Y Han and H Xue (1999) Central benzodiazepine binding site ligands. CNS Drug Reviews. 5(2):125-144
     
47. Xue, H, J Hang, R Chu, Y Xiao, H Li, P Lee, and H Zheng (1999) Delineation of a membrane-proximal b-rich domain in GABAA receptor by progressive deletions. J. Mol. Biol. 285(1):55-61
     
48. Li, CY, H Xue, H Wang, PR Carlier, KM Hui, YP Pang, ZW Li and YF Han (1999) Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABAA receptor antagonist. NeuroReport. 10:795-800
     
49. Xue, H (1998) Identification of major phylogenetic branches of inhibitory ligand gated channel receptors. J. Mol. Evol. 47:323-333
     
50. Xue, H, RA Chu, J Hang, P Lee and H Zheng (1998) Fragment of GABAA receptor containing key ligand-binding residues overexpressed in Escherichia coli. Protein Science.7:216-219
     
51. Smith, DK and H Xue (1998) A major component approach to present consensus sequences. Bioinformatics. 14:151-156
     
52. Zhang, B, H Xue and B. Lin (1998) Application of capillary zone electrophoresis to the study of interaction between Bacillus subtilis tryptophanyl-tRNA synthetase and tRNATrp. Chromatographia. 48:268-272
     
53. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Construction and application of gene targeting replacement vector for mouse coagulation factor IX gene. J Med Coll PLA 13:106-110
     
54. Xue, H, H Zheng and XF Wu (1998) Preparation of highly purified hemoglobin by affinity elution. Art. Cells, Blood Subs. & Immob. Biotech. 26(3):317-327
     
55. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Targeted disruption of coagulation factor IX gene in mouse embryonic stem cells. Acad. J. Second. Milit. Med. Univ. 19 (1): 1-4 (Chinese)
     
56. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Construction and application of gene targeting replacement vector. Acad. J. Second. Milit. Med. Univ. 19 (1): 5-8 (Chinese)
     
57. Dai, X, H Xue and J Fu (1998) Genomic structural analysis and targeted disruption of mouse coagulation factor IX gene in ES cells. J. Fudan Uni. (Natural Sci.) 37:577-578 (Chinese)
     
58. Dai, X, H Xue, H Yang, Y Hu and J Fu (1998) Separating /combining strategy for restriction mapping the large genomic insert in recombinant phage vector. Prog. Biochem. Biophys. 25(5):454-459 (Chinese)
     
59. Xue, H, YL Xue, S Doubli and CW Carter (1997) Chemical modification of Bacillus subtilis tryptophanyl-tRNA synthetase. Biochem. and Cell Biol. 75:709-715
     
60. Smith, DK and Xue, H (1997) Sequence profiles of immunoglobulin and immunoglobulin-like domains. J. Mol. Biol. 274:530-545
     
61. Dai, X, H Xue, H Yang, Y Hu and J Fu (1997) Application of PCR and genomic southern blotting to molecular identification of homologous recombination events in gene targeting. Chinese J. Med. Genet. 14(6):339-343 (Chinese)
     
62. Hogue, CWV, S Douli, H Xue, JT Wong, CW Carter and AG Szabo (1996) A concerted tryptophanyl-adenylate-dependent conformational change in Bacillus subtilis tryptophanyl-tRNA synthetase revealed by the fluorescence of Trp92. J. Mol. Biol. 260:446-466
     
63. Xue, H and JT Wong (1995) Interferon induction of human tryptophanyl-tRNA synthetase safeguards the synthesis of tryptophan-rich immune system proteins: a hypothesis. Gene 165:335-339
     
64. Xue, H, WY Shen, R Giege and JT Wong (1993) Identity elements of Bacillus subtilis tRNATrp: Identification and evolutionary conservation. J. Biol. Chem. 268:9316-9322
     
65. Xue, H, A Glasser, J Desgress, H Grosjean (1993) Modified nucleosides in Bacillus subtilis tRNATrp hyperexpressed in Escherichia coli. Nuleic Acids Research 21:2479-2486
     
66. Xue, H, WY Shen and JT Wong (1993) Purification of hyperexpressed Bacillus subtilis tRNATrp gene cloned in Escherichia coli. J. Chromatography 613:247-255
     
67. Ala, P, H Xue, L Leung, YQ Xue, JT Wong and DDS Yang (1993) Purification and crystallization of tryptophanyl-tRNA synthetase. J. Mol. Biol. 230:1089-1090
     
68. Xue, H and YF Zhang (1992) Pulmonary fat embolism in rabbits induced by forced immobilization. J. Trauma 32:415-419
     
69. Chow, KC, Xue H, W Shi and JT Wong (1992) Mutational identification of an essential tryptophan in tryptophanyl-tRNA synthetase of Bacillus subtilis. J. Biol. Chem. 267:9146-9149
     
70. Xue, H, XF Wu and JT Wong (1992) Properties of hemoglobin and dextran-hemoglobin rightshifted by oxidized inositol tetrakisphosphate. Aritificial Organs, 16:14-18
     
71. Xue, H and YF Zhang (1988) Pulmonary fat embolism induced by forced immobilization in rabbits. J Med Coll PLA , 3:236-240
     
72. Xue, H (1988) Fat embolism as a result of interior environment disorder. International Medicine: Physiological, Pathophysiological and Clinical Sciences Section, 4:193-195 (Chinese)

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