Division of Life Science
 
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Jun XIA

PhD Johns Hopkins
Professor

Email: jxia@ust.hk

 

Research Interests

Molecular and cellular basis of learning and memory, organization of synapse and regulation of synaptic transmission.

Molecular mechanism of protein trafficking and its implication in brain disorder and diabetes.

 

Selected Publications

1.     Xu J, Kam C, Luo J, Xia J*. (2014) PICK1 Mediates Synaptic Recruitment of AMPA Receptors at Neurexin-induced Postsynaptic Sites. J. Neurosci. 34(46):15415-15424

2.     Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KKY, Xu A, Lee KM, Jiang L and Xia J* (2013). PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance. PLOS Biology, 11(4): e1001541.

3.     Fu AK, Hung KW, Fu WY, Shen C, Chen Y, Xia J, Lai KO, Ip NY (2011). APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nat. Neurosci. 14(2):181-9.

4.     Xu J, Xiao N, Xia J* (2010). Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nat. Neurosci. 13(1):22-4.

5.     Xiao N, Kam C, Shen C, Jin W, Wang J, Lee KM, Jiang L and Xia J* (2009). PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. J. Clin Invest. 119(4):802-812.

6.     Cao M, Xu J, Shen C, Kam C, Huganir RL and Xia J* (2007). PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. J. Neurosci. 27(47):12945-12956.

7.    Pan L, Wu H, Shen C, Shi Y, Jin W, Xia J* and Zhang M* (2007). Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. 26(21):4576-87 *Co-corresponding authors.

8.   Jin W, Ge W, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M and Xia J* (2006). Lipid Binding Regulates PICK1’s Synaptic Targeting, AMPA Receptor Trafficking and Synaptic Plasticity. J. Neurosci. 26(9):2380-2390

9.   Xia J, Chung HJ, Wihler C, Huganir RL and Linden DJ (2000). Cerebellar Long-Term Depression Requires PKC Regulated Interactions Between GluR2/3 and PDZ Domain-Containing Proteins. Neuron, 28(2):499-510.

10.  Xia J, Zhang X, Staudinger J, Huganir RL. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.  Neuron 22(1):179-87.

 

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