Division of Life Science
 
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Robert K.M. KO

PhD British Columbia
Professor

Email: bcrko@ust.hk

Laboratory Homepage

Research Interests
Antioxidant mechanism(s) of Chinese tonic herbs with focus on the regulation of cellular glutathione redox status; Pharmacological basis of Yang/Qi-invigoration in Chinese medicine.

Representative Publications

For a full list of publications with abstract, please click here

  1. Chiu, P.Y., Tang, M.H., Mak, D.H.F., Poon, M.K.T., and Ko, K.M. (2003). Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radic. Biol. Med. 35: 368-380.
  2. Ko, K.M., Mak, D.H.F., Chiu, P.Y., and Poon, M.K.T. (2004). Pharmacological basis of “Yang – invigoration” in Chinese medicine. Trends Pharmacol. Sci. 25: 3-6.
  3. Chiu, P.Y., and Ko, K.M. (2004). Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats. Mol. Cell. Biochem. 266: 139-144.
  4. Siu, K.M., Mak, D.H.F., Chiu, P.Y., Poon, M.K.T., Du, Y., and Ko, K.M. (2004). Pharmacological basis of ‘Yin-nourishing’ and ‘Yang-invigorating’ actions of Cordyceps, a Chinese tonifying herb. Life Sci. 76: 385-395.
  5. Chiu, P.Y., Mak, D.H.F., Poon, M.K.T., and Ko, K.M. (2005). Role of cytochrome P-450 in schisandrin B induced antioxidant and heat shock responses in mouse liver. Life Sci. 77: 2887-2895.
  6. Ko, K.M., and Chiu, P.Y. (2005). Structural determinants of schisandrin B for enhancing mitochondrial functional and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells. Mol. Cell. Biochem. 276: 227-234.
  7. Du, Y., and Ko, K.M. (2005). Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: Single versus multiple doses and gender difference. Life Sci. 77: 2770-2782.
  8. Leung, H.Y., Chiu, P.Y., Poon, M.K.T., and Ko, K.M. (2005). A Yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats. Rejuvenation Res. 8: 238-247.
  9. Du, Y., and Ko, K.M. (2006). Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and a-tocopherol in rats. Planta Med. 72: 222-227
  10. Ko, K.M., and Chiu, P.Y. (2006). Biochemical basis of the “Qi-invigorating” action of Schisandra berry (Wu-Wei-Zi) in Chinese medicine. Am. J. Chin. Med. 34: 171-176.
  11. Chiu, P.Y., Leung, H.Y., Poon, M.K.T., Lee, S.S.T., and Ko, K.M. (2006). Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver. Mol. Cell. Biochem. 293: 87-92
  12. Ko, K.M., Leon, T.Y.Y., Mak, D.H.F., Chiu, P.Y., Du, Y., and Poon, M.K.T. (2006). A characteristic pharmacological action of ‘Yang-invigorating’ Chinese tonifying herbs: Enhancement of myocardial ATP generation capacity. Phytomedicine 13: 636-642.
  13. Du, Y., Ko, K.M. (2006). Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts. Mol. Cell. Biochem. 288: 135-142.
  14. Mak, D.H.F., Chiu, P.Y., Dong, T.T.X., Tsim, K.W.K., and Ko, K.M. (2006). Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytother. Res. 20: 561-567.
  15. Chiu, P.Y., Leung, H.Y., Poon, M.K.T., Mak, D.H.F., and Ko, K.M. (2006). (-) Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes. Mol. Cell. Biochem. 289: 185-191.
  16. Chiu, P.Y., Leung, H.Y., Poon, M.K.T., and Ko, K.M. (2006). Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats. Biogerontology 7: 199-210.
  17. Chiu, P.Y., and Ko, K.M. (2006). Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells. Biofactors 26: 221-230.
  18. Chiu, P.Y., Leung, H.Y., Siu, A.H.Y., Poon, M.K.T., Dong, T.T.X., Tsim, K.W.K., and Ko, K.M. (2007) Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: Role of glutathione synthesis and regeneration. Planta Med. 73:134-141.
  19. Ko, K.M., and Leung, H.Y. (2007). Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities of Chinese Yang and Yin tonifying herbs. Chin. Med. 2:3 doi:10.1186/1749-8546-2-3.
  20. Chiu, P.Y., Leung, H.Y., Siu, A.H.L., Poon, M.K.T., and Ko, K.M. (2007). Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers. Biol. Pharm. Bull. 30: 1108-1112.
  21. Poon, M.K.T., Chiu, P.Y., Leung, H.Y., Siu, A.H.L., and Ko, K.M. (2008). A ‘Yang-invigorating Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats. Phytother. Res. 22: 131-133.
  22. Chiu, P.Y., Leung, H.Y., Siu, A.H.L., Chen, N., Poon, M.K.T., and Ko, K.M. (2008). Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. Rejuvenation Res. 11: 43-62.
  23. Leung, H.Y., and Ko, K.M. (2008). Cistanche deserticola extract enhances mitochondrial ATP generation in rat hearts and H9c2 cells: Pharmaceut. Biol. 46: 418-424.
  24. Chiu, P.Y., Leung, H.Y., and Ko, K.M. (2008). Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats. Biol. Pharm. Bull. 31: 602-605.
  25. Chiu, P.Y., Luk, K.F., Leung, H.Y., Ng, K.M., and Ko, K.M. (2008). Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes. Life Sci. 82: 1092-1101.
  26. Chen, N., Chiu, P.Y., and Ko, K.M. (2008). Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats. Biol. Pharm. Bull. 31: 1387-1391.
  27. Zhang, G.Q., Yu, Z.L., Liu, W.T., Wang, H., Fong, W.F., Tang, L.M., Xiong, Y.H., and Ko, K.M. (2008). Long-term treatment with a Chinese herbal formula, Sheng-Mai-San, improves cardiac contractile function in aged rats: The role of Ca2+ homeostasis. Rejuvenation Res. 11: 989-990.

 

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