Division of Life Science
 
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Randy Y.C. POON

PhD Cambridge
Chair Professor
Director, Center for Cancer Research
Director, Biosciences Central Research Facility

Email: rycpoon@ust.hk

 

Research Interests
The molecular basis of cell cycle control in normal and cancer cells.

For more publications see Poon Lab Home Page

Recent publication (last 5 years)

  1. Ma, H.T. and Poon, R.Y.C. (2017) Synchronization of HeLa cells. Methods Mol. Biol. 1524: 189-201.
     
  2. Wang, X.Q., Lo, C.M., Chen, L., Ngan, E.S., Xu, A., and Poon, R.Y.C. (2017) CDK1-PDK1-PI3K/Akt-signaling pathway regulates embryonic and induced pluripotency. Cell Death & Differentiation 24: 38-48.
     
  3. Xia, W., Lo, C.M., Poon, R.Y.C., Cheung, T.T., Chan, A.C.Y., Chen, L., Yang, S., Tsao, G.S.W., and Wang, X.Q. (2017) Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells. Oncotarget 8: 38811-24.
     
  4. Huang, S., Tang, R., and Poon, R.Y.C. (2016) BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death. Oncotarget 7: 38718-30.
     
  5. Ma, H.T. and Poon, R.Y.C. (2016) TRIP13 regulates both the activation and inactivation of the spindle-assembly checkpoint. Cell Reports 14: 1086-99.
     
  6. Poon, R.Y.C. (2016) Cell cycle control: a system of interlinking oscillators. Methods Mol. Biol. 1342: 3-19.
     
  7. Wong, P.Y., Ma, H.T., Lee, H, and Poon, R.Y.C. (2016) MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation. Scientific Reports 6: 22230.
     
  8. Li, J., Hong, M.J., Chow, J.P.H., Man, W.Y., Mak, J.P.Y., Ma, H.T., and Poon, R.Y.C. (2015) Co-inhibition of Polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. Oncotarget 6: 9327-40.
     
  9. Mak, J.P.Y., Man, W.Y., Chow, J.P.H., Ma, H.T., and Poon, R.Y.C. (2015) Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells. Oncotarget 6: 21074-84.
     
  10. Poon, R.Y.C. (2015) Cell cycle control. Reference Module in Biomedical Sciences. Elsevier. 08-Aug-2015 doi: 10.1016/B978-0-12-801238-3.98748-8.
     
  11. Poon, R.Y.C. (2015) Mitotic catastrophe. In Encyclopedia of Cell Biology, 1st Edition. Ed Bradshaw & Stahl. Academic Press, San Diego, p 399-403.
     
  12. Wong, W.K., Kelly, T., Li, J., Ma, H.T., and Poon, R.Y.C. (2015) SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A–B56. Cell Cycle 14: 3965-77.
     
  13. Xie, S., Mortusewicz, O., Ma, H.T., Herr, P., Poon, R.Y.C., Helleday, T., and Qian, C. (2015) Timeless interacts with PARP-1 to promote homologous recombination repair. Molecular Cell 60: 163-76.
     
  14. Chen, H., Huang, S., Han, X., Zhang, J., Shan, C., Tsang, Y.H., Ma, H.T., and Poon, R.Y.C. (2014) Salt-Inducible Kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutics-mediated cell death. Cell Death & Disease 5: e1177.
     
  15. Ma, H.T., Erdal, S., Huang, S., and Poon, R.Y.C. (2014) Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance. Mol. Oncology 8: 1408-18.
     
  16. Mak, J.P.Y., Man, W.Y., Ma, H.T., and Poon, R.Y.C. (2014) Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget 5:10546-57.
     
  17. Man, W.Y., Mak, J.P.Y., and Poon, R.Y.C. (2014) Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint. J. Cell. Mol. Med. 18: 143-55.
     
  18. Marxer, M., Ma, H.T., Man, W.Y., and Poon, R.Y.C. (2014) p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases. Oncogene 33: 3550-60.
     
  19. Poon, R.Y.C. (2014) DNA damage checkpoints in nasopharyngeal carcinoma. Oral Oncology 50: 339-44.
     
  20. Wang, X.Q., Chan, K.K., Ming, X., Lui, V.C.H., Poon, R.Y.C., Lo, C.M., Norbury, C., and Poon R.T.P. (2014) G1 checkpoint establishment in vivo during embryonic liver development. BMC Devel. Biol. 14: 23.
     
  21. Xing, X., Poon, R.Y.C., Wong, C.S.C., and Yobas, L. (2014) Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes. Biosensors and Bioelectronics 61: 434-42.
     
  22. Chow, J.P.H., Man, W.Y., Mao, M., Chen, H., Cheung, F. Nicholls, J., Tsao, G.S.W., Lung, M.L., and Poon, R.Y.C. (2013) Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy. Mol. Cancer Therap. 12: 2517-28.
     
  23. Chow, J.P.H. and Poon, R.Y.C. (2013) The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery. Oncogene 32: 4778-88.
     
  24. Han, X. and Poon, R.Y.C. (2013) Critical differences between isoforms of Securin reveal mechanisms of Separase regulation. Mol. Cell. Biol. 33: 3400-15 (Spotlight article).
     
  25. Poon, R.Y.C. (2013) News and Views. Aurora B: hooking up with cyclin-dependent kinases. Cell Cycle 12: 1019-20.
     

 

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