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Randy Y.C. POON
PhD Cambridge
Professor
Director, Center for Cancer Research
Director, Biosciences Central Research Facility

Email: rycpoon@ust.hk

 
Research Interests
The molecular basis of cell cycle control in normal and cancer cells.

For more publications see Poon Lab Home Page

Representative Publications

  1. Ma, H.T. and Poon, R.Y.C. (2011) Orderly inactivation of the key checkpoint protein Mitotic Arrest Deficient 2 (MAD2) during mitotic progression.  J. Biol. Chem. 286: 13052-9.
     
  2. Chow, J.P.H., Poon, R.Y.C., and Ma, H.T. (2011) Inhibitory phosphorylation of CDK1 as a compensatory mechanism for mitotic exit.  Mol. Cell. Biol.  31: 1478-91.
     
  3. On, K.F., Chen, Y., Ma, H.T., Chow, J.P.H., and Poon, R.Y.C. (2011) Determinants of mitotic catastrophes upon abrogation of the G2 DNA damage checkpoint by UCN-01.  Mol. Cancer Therap. 10: 784-94. 
     
  4. Ho, C.C., Hau, P.M., Marxer, M., and Poon, R.Y.C. (2010) The requirement of p53 for maintaining chromosomal stability during tetraploidization.  Oncotarget 1: 583-95.
     
  5. Ma, H.T. and Poon, R.Y.C. (2010) Genome reduplication: redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C.  Cell Cycle 9: 431-2.
     
  6. Ma, H.T. and Poon, R.Y.C. (2010) Gene downregulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells. Current Protocols in Cell Biology Chapter 27:Unit27.2.
     
  7. Chan, Y.W., Chen, Y., and Poon, R.Y.C. (2009) Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe. Oncogene  28: 170-183.
     
  8. Ma, H.T., Tsang, Y.H., Marxer, M., and Poon, R.Y.C. (2009) Cyclin A2-CDK2 cooperates with the PLK1-SCFb-TrCP1-EMI1-APC/C axis to promote genome reduplication in the absence of mitosis. Mol. Cell. Biol.  29: 6500-6514.
     
  9. Uchida, S., Yoshioka, K., Kizu, R., Nakagama, H., Matsunaga, T., Ishizaka, Y., Poon, R.Y.C., and Yamashita, K. (2009) Stress-activated MAP kinases JNK and p38 target Cdc25B for degradation. Cancer Res. 69: 6438-44.
     
  10. Wang, X.Q., Liu, V.C.H., Poon, R.T.P., Lu, P., and Poon, R.Y.C. (2009) DNA damage-mediated S and G2 checkpoints in human embryonal carcinoma cells.  Stem Cells 27: 568-76.
     
  11. Chan, Y.W., Ma, H.T., Wong, W., Ho, C.C., On, K.F., and Poon, R.Y.C. (2008) CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. Cell Cycle 7: 1149-61.
     
  12.  Chan, Y.W., On, K.F., Chan, W.M., Wong, W., Siu, H.O., Hau, P.M., and Poon, R.Y.C. (2008) The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.  J. Biol. Chem.  283: 15716-23.
     
  13. Chan, W.M. and Poon, R.Y.C. (2007) The p53 isoform ∆p53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity.  Cancer Res. 67: 1959-69.
     
  14. Fung, T.K., Ma, H.T., and Poon, R.Y.C. (2007) Specialized roles of the two mitotic cyclins in somatic cells: Cyclin A as an activator of M phase-promoting factor.  Mol. Biol. Cell 18: 1861-73.
     
  15. Ma, H.T., On, K.F., Tsang, Y.H., and Poon, R.Y.C. (2007) An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells.  Nucleic Acids Res. 35: e22 (doi: 10.1093/nar/gkl1109).
     
  16. Zhang, W., Chan, H.M., Poon, R.Y.C., and Wu, Z. (2007) BS69 is involved in cellular senescence through the p53-p21cip1 pathway.  EMBO Reports 8: 952-8. 

     

Recent Review Articles

  1. Ma, H.T. and Poon, R.Y.C. (2011) How protein kinases coordinate mitosis in animal cells. Biochem. J. 435: 17-31.
     
  2. Poon, R.Y.C. (2011) Cyclin A. In Encyclopedia of Signalling Molecules. Springer, New York. in press.
     
  3. Chow, J.P.H. and Poon, R.Y.C. (2010) DNA damage and polyploidization. In Polyploidization and Cancer. Ed. Randy Y.C. Poon Springer, New York. 55-69.
     
  4. Chow, J.P.H. and Poon, R.Y.C. (2010) Mitotic catastrophe. In Cell Cycle Deregulation in Cancer 79-96. Ed. Greg Enders. Springer, New York.
     
  5. Poon, R.Y.C. (book editor) (2010) Polyploidization and Cancer. Springer, New York.
     
  6. Chen, Y. and Poon, R.Y.C. (2008) The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. Frontiers Biosciences 13: 5016-29.
     
  7. Poon, R.Y.C. (2007) Mitotic phosphorylation: breaking the balance of power by a tactical retreat. Biochem. J. 403: e5-7.
     
  8. Poon, R.Y.C. and Fung, T.K. (2007) Cyclin A2. AfCS-Nature Molecule Pages. (doi:10.1038/mp.a000717.01).

 

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