Division of Life Science
 
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Randy Y.C. POON

PhD Cambridge
Chair Professor
Director, Center for Cancer Research
Director, Biosciences Central Research Facility

Email: rycpoon@ust.hk

 

Research Interests
The molecular basis of cell cycle control in normal and cancer cells.

For more publications see Poon Lab Home Page

Recent publication (last 5 years)

  1. Li, J., Hong, M.J., Chow, J.P.H., Man, W.Y., Mak, J.P.Y., Ma, H.T., and Poon, R.Y.C. (2015) Co-inhibition of Polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. Oncotarget 6: 9327-40.
     
  2. Mak, J.P.Y., Man, W.Y., Chow, J.P.H., Ma, H.T., and Poon, R.Y.C. (2015) Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells. Oncotarget 6: 21074-84.
     
  3. Poon, R.Y.C. (2015) Cell cycle control. Reference Module in Biomedical Sciences. Elsevier. 08-Aug-2015 doi: 10.1016/B978-0-12-801238-3.98748-8.
     
  4. Wong, W.K., Kelly, T., Li, J., Ma, H.T., and Poon, R.Y.C. (2015) SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A–B56. Cell Cycle 14: 3965-77.
     
  5. Xie, S., Mortusewicz, O., Ma, H.T., Herr, P., Poon, R.Y.C., Helleday, T., and Qian, C. (2015) Timeless interacts with PARP-1 to promote homologous recombination repair. Mol. Cell 60: 163-76.
     
  6. Chen, H., Huang, S. Han, X., Zhang, J., Shan, C., Tsang, Y.H., Ma, H.T., and Poon, R.Y.C. (2014) Salt-Inducible Kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutics-mediated cell death. Cell Death & Disease 5: e1177.
     
  7. Ma, H.T., Erdal, S., Huang, S., and Poon, R.Y.C. (2014) Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance. Mol. Oncology 8: 1404-18.
     
  8. Mak, J.P.Y., Man, W.Y., Ma, H.T., and Poon, R.Y.C. (2014) Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth simulation and apoptosis. Oncotarget 5:10546-57.
     
  9. Man, W.Y., Mak, J.P.Y., and Poon, R.Y.C. (2014) Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint. J. Cell. Mol. Med. 18: 143- 55.
     
  10. Marxer, M., Ma, H.T., Man, W.Y., Poon, R.Y.C. (2014) p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases. Oncogene 33: 3550-60.
     
  11. Poon, R.Y.C. (2014) DNA damage checkpoints in nasopharyngeal carcinoma. Oral Oncology 50: 339-44.
     
  12. Wang, X.Q., Chan, K.K., Ming, X., Lui, V.C.H., Poon, R.Y.C., Lo, C.M., Norbury, C., and Poon, R.T.P. (2014) G1 checkpoint establishment in vivo during embryonic liver development. BMC Developmental Biology 14: 23.
     
  13. Xing, X., Poon, R.Y.C., Wong, C.S.C., Yobas, L. (2014) Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes. Biosensors and Bioelectronics 61: 434-42.
     
  14. Chow, J.P.H., Man, W.Y., Mao, M., Chen, H., Cheung, F. Nicholls, J., Tsao, G.S.W., Lung, M.L., Poon, R.Y.C. (2013) Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy. Mol. Cancer Therap. 12: 2517-28.
     
  15. Chow, J.P.H. and Poon, R.Y.C. (2013) The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery. Oncogene32: 4778-88.
     
  16. Han, X. and Poon, R.Y.C. (2013) Critical differences between isoforms of Securin reveal mechanisms of Separase regulation. Mol. Cell. Biol. 33: 3400-15 (Spotlight article).
     
  17. Poon, R.Y.C. (2013) News and Views. Aurora B: hooking up with cyclin-dependent kinases. Cell Cycle 12: 1019-20.
     
  18. Chen, Y., Chow, J.P.H., and Poon, R.Y.C. (2012) Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe. Mol. Cancer Res. 10: 626-35.
     
  19. Ma, H.T., Chan, Y.Y., Chen, X., On, K.F., and Poon, R.Y.C. (2012) Depletion of p31comet promotes sensitivity to antimitotic drugs. J. Biol. Chem. 287: 21561-9.
     
  20. Marxer, M., Foucar, C.E., Man, W.Y., Chen, Y., Ma, H.T., and Poon, R.Y.C. (2012) Tetraploidization increases sensitivity to Aurora B kinase inhibition. Cell Cycle 11: 2567-77.
     
  21. Poon, R.Y.C. (2012) Cyclin A. In Encyclopedia of Signalling Molecules. Ed. Sangdun Choi. Springer, New York. p. 491-6.
     
  22. Tsang, Y.H., Han, X., Man, W.Y., Lee, N., and Poon, R.Y.C. (2012) Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. PLos ONE 7: e49943.
     
  23. Chow, J.P.H., Poon, R.Y.C., and Ma, H.T. (2011) Inhibitory phosphorylation of CDK1 as a compensatory mechanism for mitotic exit. Mol. Cell. Biol. 31: 1478-91.
     
  24. Ma, H.T. and Poon, R.Y.C. (2011) Orderly inactivation of the key checkpoint protein Mitotic Arrest Deficient 2 (MAD2) during mitotic progression. J. Biol. Chem. 286: 13052-9.
     
  25. Ma, H.T. and Poon, R.Y.C. (2011) How protein kinases coordinate mitosis in animal cells. Biochem. J. 435: 17-31.
     
  26. Ma, H.T. and Poon, R.Y.C. (2011) Synchronization of HeLa cells. Methods Mol. Biol. 761: 151-61.
     
  27. On, K.F., Chen, Y., Ma, H.T., Chow, J.P.H., and Poon, R.Y.C. (2011) Determinants of mitotic catastrophes upon abrogation of the G2 DNA damage checkpoint by UCN-01. Mol. Cancer Therap. 10: 784-94.
     
  28. Poon, R.Y.C. (2011) Biomedical research in Hong Kong. The Biochemist 33: 24-25.
     
  29. Uchida, S., Watanabe, N., Kudo, Y., Yoshioka, K., Matsunaga, T., Ishizaka Y., Nakagama, H., Poon, R.Y.C., Yamashita, K. (2011) SCFbeta-TrCP mediates stress-activated MAP kinase-induced Cdc25B degradation. J. Cell Science 124: 2816-25.
     

 

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