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First Name LAST NAME

PhD Cornell University
Professor

Email: boyxie@ust.hk

 

Research Interests
Cancer and viral immunology (including vaccine development for cancer and infectious diseases)..

Summary of research
Dr Xie's major research interest is cancer and viral immunology. Currently, his lab is attempted to develop tumor vaccines for human hepatocellular carcinoma using fusion-based biotechnology. Dr Xie is also studying the immunogenicity of viruses in human and animal infectious diseases, such as swine foot-and-mouth disease (sFMD) and human papillomavirus (HPV).

 

Representative Publications

  1. Qin Yan, Ying-Kit Cheung, Samuel Chak-Sum Cheng, Wang Xian-Hua, Meng Shi, Hu Mei-Hao, Xie Yong (2006). A DNA vaccine constructed with human papillomavirus type 16 (HPV16) E7 and E6 genes induced specific immune responses. Gynecol Oncol. (in press).
     

  2. Qin Y., Wang X.H., Cui H.L., Cheung Y.K., Hu M.H., Zhu S.G. Xie Y. (2005). Human papillomavirus type 16 E7 peptide (38-61) linked with an immunoglobulin G fragment provides protective immunity in mice. Gynecol. Oncol. 96(2): 475-83.
     

  3. Wang X.H., Qin Y., Hu M.H., Xie Y. (2005). Dendritic cells pulsed with gp96-peptide complexes derived from human hepatocellular carcinoma (HCC) induce specific cytotoxic T lymphocytes. Cancer Immunol. Immunoth. 54(10): 971-80.
     

  4. Wang X.H., Qin Y., Hu M.H., Xie Y. (2005). Dendritic cells pulsed with hsp70-peptide complexes derived from human hepatocellular carcinoma induce anti-tumor immune responses. World J. Gastroenterol. 11(36): 5614-5620.
     

  5. Cheng C-S Samuel, Zhou Jing, Xie Yong. (2005). P-glycoprotein expression induced by glucose depletion enhanced the chemosensitivity in human hepatocellular carcinoma cell-lines. Cell Biol. Int. 29(4): 269-75.
     

  6. Zhong X., Yang H., Guo Z.F., Sin W.Y., Chen W., Xu J., Fu L., Wu J., Mak C.K., Cheng C-S.S., Yang Y., Cao S., Wong T.Y., Lai S.T., Xie Y*., Guo Z*. (2005). B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein. J. Virol. 79(6): 3401-8. (* = corresponding authors).
     

  7. Ying-Kit Cheung, Samuel C-S Cheng, Fion W-Y Sin, Yong Xie (2004). Plasmid encoding papillomavirus Type 16 (HPV16) DNA constructed with codon optimization improved the immunogenicity against HPV infection. Vaccine 23: 629-638.
     

  8. Wang Y-D#, Sin W-Y Fion#, Xu G-B#, Yang H-H, Wong T-Y, Pang X-W, He X-Y, Zhang H-G, Ng N-L Joice, Cheng C-S Samuel, Yu J ,Meng L Lily, Yang R-F, Lai S-T, Guo Z-H , Xie Y*, Chen W-F* (2004). T cell epitoped in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS. J. Virol. 78 (11): 5612-5618. (# equal contribution; * correspondence authors).
     

  9. Ray C-F Chan, Y Xie (2004). CD80 transfected human hepatocellular carcinoma (HCC) cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor antigens. Oncology Reports. 12(2): 435-442.
     

  10. Ray C-F Chan, XW Pang, YD Wang, WF Chen, Y Xie (2004). Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells. Brit. J. Cancer. 90:1636-1643.
     

  11. Chan Ray C-F, Zhao G-P, Xie H, Xie Y. (2002). Dendritomas formed by mature dendritic cells with human hepatocellular carcinoma cells activate cytotoxic T Lymphocytes. Immunol. Letters. 83 (2): 101-109.
     

  12. Huang X, Zeng R, Ding X, Mao X, Ding Y, Rao Z, Xie Y, Jiang W, Zhao G. (2002). Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130. J. Biol. Chem. Mar 22; 277 (12): 10256-64.
     

  13. Xiong D, Xu Y, Liu H, Peng H, Shao X, Lai Z, Fan D, Yang M, Han J, Xie Y, Yang C, Zhu Z. (2002). Efficient inhibition of human B-cell lymphoma xenografts with an anti-CD20 x anti-CD3 bispecific diabody. Cancer Letters. Mar 8; 177 (1): 29-39.
     

  14. Wong Ho-Tsun, Cheng Samuel C-S, Chan Ella W-C, Sheng Z-T, Zhu L-Q, Xie Y. (2002) A DNA vaccine against foot-and-mouth disease elicits an immune response in swine which is enhanced by co-administration with interleukin-2. Vaccine. 20: 2641-2647.
     

  15. Chan Kin-Tak, Cheng Samuel C-S, Xie Hong, Xie Yong. (2001). A humanized monoclonal antibody constructed from intronless expression vectors targets human hepatocellular carcinoma cells. Biochem Biophy Res Com.284: 157-167.
     

  16. Cheng Samuel C-S, Luo Dan, Xie Yong. (2001). Taxol induced Bcl-2 protein phosphorylation in human hepatocellular carcinoma QGY-7703 cell line. Cell. Biol. Int. 25 (3): 261-265.
     

  17. Chan Ella W-C, Cheng Samuel C-S, Sin Fion W-Y, Xie Yong. (2001). Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol. Letters. May 31; 122 (1): 81-87.
     

  18. Zhou Jing, Cheng Samuel C-S, Luo Dan, Xie Yong. (2001). Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR50 cell line. Biochem Biophy Res Com. 280: p1237-1242.
     

  19. Chan Ella W-C, Wong Ho-Tsun, Cheng Samuel C-S, Sheng Z-T, Yan W-Y, Zheng Z-X, Zhu L-Q, Xie Yong. (2001). An immunoglobulin G based chimeric protein induced foot-and-mouth disease specific immune response in swine. Vaccine. 19(4-5): 538-54.
     

  20. Wong Ho-Tsun, Cheng Samuel C-S, Chan Ella W-C, Sheng Z-T, Yan W-Y, Zhang Z-X, Zhu L-Q, Xie Yong. (2000). Plasmids encoding foot-and-mouth disease virus VP1 epitopes elicit immune response in mice and swine and protect swine against viral infection. Virology. 278: 27-35.
     

  21. Luo Dan, Cheng Samuel C-S, Xie Hong, Xie Yong (2000). Effects of Bcl-2 and Bcl-XL protein levels on chemoresistance of hepatoblastoma HepG2 cell line. Biochem. Cell. Biol. 78: 119-126.
     

  22. Xie Y, Zhao GP, Zhu LQ (2000). FISH mapping of human type I phosphatidylinositol 4-phosphate 5-kinase alpha. Cytogenet. Cell. Genet. 88:197-199.
     

  23. JH Yuan, RP Zheng, RG Zhang, LX Guo, XW Wang, D Luo, Y Xie, H Xie (2000). Growth-inhibiting effects of taxol on human liver cancer in vitro and in Nude mice. World J. Gastroenterol. 6(2): 210-215.
     

  24. Luo Dan, Cheng Samuel C-S, Xie Hong, Xie Yong (2000). Effects of Bcl-2 and Bcl-XL protein levels on chemoresistance of hepatoblastoma HepG2 cell line. Biochem. Cell Biol. 78: 119-126.
     

  25. Luo Dan, Cheng Samuel C-S, Xie Hong, Xie Yong (1999). Chemosensitivity of human hepatocellular carcinoma cell line QGY-7703 is related to Bcl-2 protein levels. Tumor Biol. 20(6) 331-340.
     

  26. Luo Dan, Cheng Samuel C-S, Xie Hong, Xie Yong (1999). Expression of Bcl-2 family proteins during chemotherapeutic agents induced apoptosis in hepatoblastoma HepG2 cell lines. Brit. J. Biomed. Sci. 56:114-22.
     

  27. Li HF, Ling MY, Xie Y, Xie H. (1999). Establishment of lymph node Metastatic model of mouse hepatocellular carcinoma Hca-F cells in C3H/hej mice. Oncology Res. 10: 569-573.
     

  28. Yang ZJ, Huang HB, Xu QX, Sheng ZT, Xie Y and Zheng ZX. (1999). Recombinant fusion protein and DNA vaccine against FMDV infection in guinea-pig and swine. Viral Immunol. 12 (1) 1-8.
     

  29. Berman M.E., Xie Y, Muller WA. (1996). Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and integrin activation. J. Immunol. 156(4):1515-1524.
     

  30. Xie Y, Muller W. (1993). Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1) Proc. Natl. Acad. Sci. USA. v.90, 5560-5573.

 

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