Division of Life Science
 
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Yung Hou WONG

PhD Cambridge
Chair Professor
Associate Dean of School of Science
Director of Biotechnology Research Institute
Co-Director of Molecular Neuroscience Center

Email: boyung@ust.hk

 

Research Interests
Prof. Wong’s major interests are currently focused on the delineation of the mechanisms of cell signaling, particularly those involving the G protein-coupled receptors (GPCRs). The functional capabilities of GPCRs that bind opioid peptides, melatonin, or chemokines, and their G protein-coupling specificities are examined in different cellular and animal systems. Delineation of interacting domains on the GPCRs and their associated G proteins provides a framework for understanding the fidelity of cell signaling and the creation of novel tools for drug discovery. Signal integration at the level of effectors such as adenylyl cyclase, phospholipase C, and mitogen-activated protein kinases are examined in cultured mammalian cells. In addition, the roles of GPCRs, G proteins, and RGS proteins in the regulation of cell proliferation and differentiation are examined using a variety of immunological, biochemical, pharmacological, and molecular biology techniques.

Representative Publications

  1. Lau, W.W.I., Chan, A.S.L., Poon, L.S.W., Zhu, J. and Wong, Y.H. (2013) G-beta/gamma-mediated activation of protein kinase D exhibits subunit specificity and requires G-beta/gamma-responsive phospholipase C-beta isoforms. Cell Commun. Signal. 11: 22.
     
  2. Chan, K.H., Hu, Y., Ho, M.K.C. and Wong, Y.H. (2013) Characterization of substituted phenylpropylamides as highly selective agonists at the melatonin MT2 receptor. Curr. Med. Chem. 20: 289-300.
     
  3. Lee, M.M.K., Chui, R.K.S., Tam, Y.S., Lau, H.Y.A. and Wong, Y.H. (2012) CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophages involves pertussis toxin-insensitive G-alpha-14/16 signaling and interleukin-6 release. J. Immunol. 189: 5266-5276.
     
  4. Lau, W.W.I., Ng, J.K.Y., Chan, A.S.L. and Wong, Y.H. (2012) Interleukin-6 autocrine signaling mediates melatonin MT1/2 receptor-induced STAT3 Tyr705 phosphorylation. J. Pineal Res. 52: 477-489.
     
  5. Liu, A.M.F., Lo, R.K.H., Guo, E.X., Ho, M.K.C., Ye, R.D. and Wong, Y.H. (2011) G-alpha-16 interacts with tetratricopeptide repeat 1 (TPR1) through its beta3 region to activate Ras independently of phospholipase C-beta signaling. BMC Struct. Biol. 11: 17.
     
  6. Tso, P.H., Yung, L.Y. and Wong, Y.H. (2011) RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling. Cancer Lett. 309: 199-208.
     
  7. Liu, A.M.F., Lo, R.K.H., Lee, M.M.K., Wang, Y., Yeung, W.W.S., Ho, M.K.C., Su, Y., Ye, R.D. and Wong, Y.H. (2010) Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS). Cell. Signal. 22: 1448-1458.
     
  8. Lee, M.M.K. and Wong, Y.H. (2009) "CCR1-mediated activation of nuclear factor-kappaB in THP-1 monocytic cells involves pertussis toxin-insensitive G-alpha-14 and G-alpha-16 signaling cascades", J. Leukocyte. Biol., 86: 1319-1329.
     
  9. Fu, G.M., Pang, T.H.H. and Wong, Y.H. (2008) "Naturally occurring phenylethanoid glycosides: potential leads for new therapeutics", Curr. Med. Chem., 15: 2592-2613.
     
  10. Liu, A.M.F., Lo, R.K.H., Wong, C.S.S., Morris, C., Wise, H. and Wong, Y.H. (2006) "Activation of STAT3 by G-alpha-s distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase", J. Biol. Chem., 281: 35812-35825.
     
  11. Liu, A.M.F. and Wong, Y.H. (2005) "Activation of nuclear factor kappaB by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G-alpha-14 and multiple signaling components: A mechanism requiring PKC, CaMKII, ERK and c-Src.", J. Biol. Chem., 280: 34617-34625.
     
  12. Wu, E.H.T. and Wong, Y.H. (2005) "Involvement of Gi/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC12 cells and cortical neurons", Mol. Pharmacol., 67: 1195-1205.
     
  13. Ho, M.K.C., Chan, J.H.P., Wong, C.S.S. and Wong, Y.H. (2004) "Identification of a stretch of six divergent amino acids on the alpha5 helix of G-alpha-16 as a major determinant for the promiscuity and efficiency of receptor coupling", Biochem. J., 380: 361-369.
     
  14. Liu, A.M.F. and Wong, Y.H. (2004) G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C and ERK signaling. J. Biol. Chem. 279: 53196-53204.
     
  15. Tian, Y.J., New, D.C., Yung, L.Y., Allen, R.A., Slocombe, P.M., Twomey, B.M., Lee, M.M.K. and Wong, Y.H. (2004) Differential chemokine activation of CCR1-regulated pathways: selective activation of G-alpha-14-coupled pathways. Eur. J. Immunol. 34: 785-795.
     
  16. Lo, R.K.H., Cheung, H. and Wong, Y.H. (2003) "Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism", J. Biol. Chem., 278: 52154-52165.
     
  17. Kam, A.Y.F., Chan, A.S.L. and Wong, Y.H. (2003) Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor. J. Neurochem. 84: 503-513.
     
  18. Ho, M.K.C. and Wong, Y.H. (2001) Gz signaling: emerging divergence from Gi signaling. Oncogene 20: 1615-1625.
     
  19. Law, P.Y., Wong, Y.H. and Loh, H.H. (2000) Molecular mechanisms and regulation of opioid receptor signaling. Ann. Rev. Pharmacol. Toxicol. 40: 389-430.
     
  20. Mody, S.M., Ho, M.K.C., Joshi, S.A. and Wong, Y.H. (2000) Incorporation of G-alpha-z-specific sequence at the carboxyl terminus increases the promiscuity of G-alpha-16 towards Gi-coupled receptors. Mol. Pharmacol. 57: 13-23.

 

Biotechnology Research Institute Homepage: http://www.ust.hk/~bri/index.html
Molecular Neuroscience Center Homepage: http://www.ust.hk/~mnc/
Central Allocation Grant (CAG) Project website: http://www.ust.hk/~stn/

 

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