Associate Dean of School of Science
Director of Biotechnology Research Institute
Co-Director of Molecular Neuroscience Center
Wong’s major interests are currently focused on the delineation of
the mechanisms of cell signaling, particularly those involving the G
protein-coupled receptors (GPCRs). The functional capabilities of
GPCRs that bind opioid peptides, melatonin, or chemokines, and their
G protein-coupling specificities are examined in different cellular
and animal systems. Delineation of interacting domains on the GPCRs
and their associated G proteins provides a framework for
understanding the fidelity of cell signaling and the creation of
novel tools for drug discovery. Signal integration at the level of
effectors such as adenylyl cyclase, phospholipase C, and mitogen-activated
protein kinases are examined in cultured mammalian cells. In
addition, the roles of GPCRs, G proteins, and RGS proteins in the
regulation of cell proliferation and differentiation are examined
using a variety of immunological, biochemical, pharmacological, and
molecular biology techniques.
- Lau, W.W.I., Chan, A.S.L., Poon, L.S.W., Zhu, J. and Wong,
Y.H. (2013) G-beta/gamma-mediated activation of protein kinase D
exhibits subunit specificity and requires
G-beta/gamma-responsive phospholipase C-beta isoforms. Cell
Commun. Signal. 11: 22.
- Chan, K.H., Hu, Y., Ho, M.K.C. and Wong, Y.H. (2013)
Characterization of substituted phenylpropylamides as highly
selective agonists at the melatonin MT2 receptor. Curr. Med.
Chem. 20: 289-300.
- Lee, M.M.K., Chui, R.K.S., Tam, Y.S., Lau, H.Y.A. and Wong,
Y.H. (2012) CCR1-mediated STAT3 tyrosine phosphorylation and
CXCL8 expression in THP-1 macrophages involves pertussis
toxin-insensitive G-alpha-14/16 signaling and interleukin-6
release. J. Immunol. 189: 5266-5276.
- Lau, W.W.I., Ng, J.K.Y., Chan, A.S.L. and Wong, Y.H. (2012)
Interleukin-6 autocrine signaling mediates melatonin MT1/2
receptor-induced STAT3 Tyr705 phosphorylation. J. Pineal Res.
- Liu, A.M.F., Lo, R.K.H., Guo, E.X., Ho, M.K.C., Ye, R.D. and
Wong, Y.H. (2011) G-alpha-16 interacts with tetratricopeptide
repeat 1 (TPR1) through its beta3 region to activate Ras
independently of phospholipase C-beta signaling. BMC Struct.
Biol. 11: 17.
- Tso, P.H., Yung, L.Y. and Wong, Y.H. (2011) RGS19 stimulates
cell proliferation by deregulating cell cycle control and
enhancing Akt signaling. Cancer Lett. 309: 199-208.
- Liu, A.M.F., Lo, R.K.H., Lee, M.M.K., Wang, Y., Yeung, W.W.S.,
Ho, M.K.C., Su, Y., Ye, R.D. and Wong, Y.H. (2010) Galpha16
activates Ras by forming a complex with tetratricopeptide repeat
1 (TPR1) and Son of Sevenless (SOS). Cell. Signal. 22:
- Lee, M.M.K. and Wong, Y.H. (2009) "CCR1-mediated activation
of nuclear factor-kappaB in THP-1 monocytic cells involves
pertussis toxin-insensitive G-alpha-14 and G-alpha-16 signaling
cascades", J. Leukocyte. Biol., 86: 1319-1329.
- Fu, G.M., Pang, T.H.H. and Wong, Y.H. (2008) "Naturally
occurring phenylethanoid glycosides: potential leads for new
therapeutics", Curr. Med. Chem., 15: 2592-2613.
- Liu, A.M.F., Lo, R.K.H., Wong, C.S.S., Morris, C., Wise, H.
and Wong, Y.H. (2006) "Activation of STAT3 by G-alpha-s
distinctively requires protein kinase A, JNK, and
phosphatidylinositol 3-kinase", J. Biol. Chem., 281:
- Liu, A.M.F. and Wong, Y.H. (2005) "Activation of nuclear
factor kappaB by somatostatin type 2 receptor in pancreatic
acinar AR42J cells involves G-alpha-14 and multiple signaling
components: A mechanism requiring PKC, CaMKII, ERK and c-Src.",
J. Biol. Chem., 280: 34617-34625.
- Wu, E.H.T. and Wong, Y.H. (2005) "Involvement of Gi/o
proteins in nerve growth factor-stimulated phosphorylation and
degradation of tuberin in PC12 cells and cortical neurons", Mol.
Pharmacol., 67: 1195-1205.
- Ho, M.K.C., Chan, J.H.P., Wong, C.S.S. and Wong, Y.H. (2004)
"Identification of a stretch of six divergent amino acids on the
alpha5 helix of G-alpha-16 as a major determinant for the
promiscuity and efficiency of receptor coupling", Biochem. J.,
- Liu, A.M.F. and Wong, Y.H. (2004) G16-mediated activation of
nuclear factor kappaB by the adenosine A1 receptor involves c-Src,
protein kinase C and ERK signaling. J. Biol. Chem. 279:
- Tian, Y.J., New, D.C., Yung, L.Y., Allen, R.A., Slocombe,
P.M., Twomey, B.M., Lee, M.M.K. and Wong, Y.H. (2004)
Differential chemokine activation of CCR1-regulated pathways:
selective activation of G-alpha-14-coupled pathways. Eur. J.
Immunol. 34: 785-795.
- Lo, R.K.H., Cheung, H. and Wong, Y.H. (2003) "Constitutively
active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent
mechanism", J. Biol. Chem., 278: 52154-52165.
- Kam, A.Y.F., Chan, A.S.L. and Wong, Y.H. (2003) Rac and
Cdc42-dependent regulation of c-Jun N-terminal kinases by the
delta-opioid receptor. J. Neurochem. 84: 503-513.
- Ho, M.K.C. and Wong, Y.H. (2001) Gz signaling: emerging
divergence from Gi signaling. Oncogene 20: 1615-1625.
- Law, P.Y., Wong, Y.H. and Loh, H.H. (2000) Molecular
mechanisms and regulation of opioid receptor signaling. Ann.
Rev. Pharmacol. Toxicol. 40: 389-430.
- Mody, S.M., Ho, M.K.C., Joshi, S.A. and Wong, Y.H. (2000)
Incorporation of G-alpha-z-specific sequence at the carboxyl
terminus increases the promiscuity of G-alpha-16 towards Gi-coupled
receptors. Mol. Pharmacol. 57: 13-23.
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