MORE ABOUT HKUST
University News
Academic Departments A-Z
Life@HKUST
Library
Map & Directions
Jobs@HKUST
Faculty Profiles
About HKUST

Search

More About HKUST
Home Why LIFS? Careers Contact Us
HKUST HKUST Division of Life Science
Research
FacultyResearch AreasFacilities
Education
Undergraduate
ProgramsScholarshipsCurriculumAdmissionCoursesResearch ProjectsInternshipsUndergraduate Advising Team
Postgraduate
MPhil/PhD in Life SciencePhD Dual-degree ProgrammeMSc in BiotechnologyAdmissionCoursesSummer Camp
QA at HKUST
News & Events
NewsEvents
Home
January 2, 2019 by LIFS Editor News 0 comments

Prof. Mingjie Zhang and his team’s research in “Best of Cell 2018”

Earlier in 2018, Prof. Mingjie Zhang and his research team published a paper in the journal Cell, titled “Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity”. This paper has recently been selected as one of the “Best Of Cell 2018” research article collections to showcase this past year’s most exciting cell biology research.

In this study, Zeng et al. employed a biochemical reconstitution approach to show that multivalent interaction networks formed by major excitatory postsynaptic density (PSD) scaffold proteins led to the formation of PSD-like assemblies via phase separation both in solution and on supported membrane bilayers. The reconstituted PSD-like assemblies can cluster receptors, selectively concentrate enzymes, promote actin bundle formation, and expel inhibitory postsynaptic proteins.

 

Read the original HKUST news article.

Read the original LIFS news article.

 

Journal Reference:

Menglong Zeng, Xudong Chen, Dongshi Guan, Jia Xu, Haowei Wu, Penger Tong, Mingjie Zhang. Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity. Cell, 2018; DOI: 10.1016/j.cell.2018.06.047

best of postsynaptic density publication synaptic signaling
3

Related Posts

New insights into membrane trafficking regulated by ER fusion protein

July 14, 2019
Read More

Target binding mechanisms governing the WW domain-containing proteins decoded

September 21, 2019
Read More

Couple Donating HK$67K to LIFS

April 3, 2020
Read More

Pathogenesis of Usher syndrome, a hereditary deafness disease

September 30, 2019
Read More

Life science alumni workshop: discovering algae under a microscope” on alumni reunion dayPrevious Post
HKUST and Pangu BioPharma (an aTyr Pharma Subsidiary) recognized for pioneering work leading to new investigational therapeutic for lung diseaseNext Post

ADDRESS

Division of Life Science
The Hong Kong University of Science and Technology
Clear Water Bay
Kowloon, Hong Kong

PHONE

Facsimile No. :
(852) 2358 1552

Telephone No. :
(852) 2358-7272 / 7339
  • Home
  • Careers
  • Contact us
  • Faculty
  • Intranet
HKUST
PrivacySitemap
Copyright © The Hong Kong University of Science and Technology.All rights reserved.
Follow HKUST on
FacebookInstagramLinkedinYouTube
PrivacySitemap