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How a genomic maintenance interactome functions in promoting DNA replication by Dr. Xiaolan ZHAO
November 9 @ 4:00 pm - 5:30 pm HKT
Dr. Xiaolan ZHAO
Molecular Biology Department
Memorial Sloan Kettering Cancer Center, New York
A central program in organism development is faithful genome duplication in every cell cycle. A “bottle-neck” in this program is copying the regions where a replisome has to traverse much longer distance than average. These segments, often called large replicons, are at high risk for genomic instability, prone to breaks and fusions, and underlie many development abnormalities and diseases. Addressing how cells duplicate high-risk regions is an urgent task towards understanding these diseases and replication mechanisms. We took advantage of the powerful yeast model system and identified a group of highly conserved proteins important for replicating large replicons. The center of this group is a scaffold protein which interacts individually with three different complexes each has a role in regulating protein modifications, including sumoylation, ubiquitination, and checkpoint phosphorylation. I will present our new work to understand the structures and functions of these proteins and how they collaborate to aid large replicon synthesis.
(Host faculty: Prof. Bik Tye)