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LIFS Seminar Series “Novel factors that regulate aging and immunity in C. elegans” by Dr. Seung-Jae V. Lee
December 14, 2018 @ 4:00 pm - 5:30 pm HKT
Dr. Seung-Jae V. Lee
Department of Life Sciences,
Pohang University of Science and Technology (POSTECH)
Many environmental and genetic factors that influence aging have been identified for the last two decades. My laboratory aims to elucidate molecular mechanisms by which intrinsic and extrinsic factors regulate aging and lifespan by using molecular genetics of the roundworm Caenorhabditis elegans. In this talk, I will present our latest work on the identification of factors that regulate aging and immunity in C. elegans. First, I will focus on how RNA quality control systems mediated by nonsense-mediated mRNA decay contribute longevity caused by reduced insulin/IGF-1 signaling. Second, I will discuss how mitochondrial factors, including mitochondrial chaperones, regulate immunity at the organism level. Because many findings on aging regulation in C. elegans have been shown to be evolutionarily conserved, homologous mechanisms may exist in mammals including humans.
(Host faculty: Prof. Ho Yi Mak)