Division of Life Science
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PhD Rutgers
Associate Professor

Email: kailiu@ust.hk


Postdoctoral, and research assistant positions are available. Applicants who are interested can directly contact Prof. Liu.

Research Interests
Cellular and molecular mechanisms of axonal regeneration failure in adult mammalian central nervous system.

Representative Publications

  1. Weng Y-L, Wang X, Ran A, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong S, Joseph J, Dore L, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming G-L. m6A Epitranscriptomic Regulation of Axon Regeneration in the Adult Mammalian Nervous System. Neuron, 2018 Jan:97(2), 313-325. e6

  2. Lou WPK, Mateos A, Koch M, Klussmann S, Yang C, Lu N, Limpert S, Göpferich M, Zschaetzsch M, Maillo C, Senis E, Grimm D, Méndez R, Liu K, Hassan BA, Martin-Villalba A. Post-transcriptional regulation of adult CNS axonal regeneration by Cpeb1. Frontiers in Molecular Neuroscience, 2018 Jan:10, 445,

  3. Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P. The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. eLife. 2017 Jun 28;6. pii: e28021.

  4. Chen W, Lu N*, Ding Y*, Wang Y*, Chan LT, Wang X, Gao X, Jiang S, Liu K. Rapamycin-resistant mTOR activity is required for sensory axon regeneration induced by a conditioning lesion. eNeuro 2016 Dec 19. DOI: 10.1523/ENEURO.0358-16.2016 (Epub)

  5. Zeng M, Shang Y, Guo T, He Q, Yung WH, Liu K, Zhang M. A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function. Proceedings of the National Academy of Sciences 2016 May 31;113(22):E3081-90

  6. Li S*, Yang C*, Zhang L, Gao X, Wang X, Liu W, Wang Y, Jiang S, Wong YH, Zhang Y, Liu K. Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proceedings of the National Academy of Sciences 2016 Feb 16;113(7):1937-42.

  7. Willenberg R, Zukor, Liu K, He Z, Steward O. Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down. Journal of Comparative Neurology 2016 Sep 1;524(13):2654-76.

  8. Shum JW, Liu K, So KF. The progress in optic nerve regeneration, where are we? Neural Regeneration Research. 2016 Jan;11(1):32-6.

  9. Du K*, Zheng S*, Zhang Q*, Li S, Gao X, Wang J, Jiang L, Liu K. Pten deletion promotes regrowth of corticospinal tract axons 1 year after spinal cord injury. Journal of Neuroscience 2015 July 1;35(26): 9754-9763.

  10. Geoffroy CG, Lorenzana AO, Kwan JP, Lin K, Ghassemi O, Ma A, Xu N, Creger D, Liu K, He Z, Zheng B. Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice. Journal of Neuroscience 2015 Apr 22;35(16):6413-28.

  11. Fang WQ, Chen WW, Jiang L, Liu K, Yung WH, Fu AKY, Ip NY. Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice. Cell Reports 2014 Dec 11;9(5), 1635-1643.

  12. Li S*, He Q*, Wang H, Tang X, Ho KW, Gao X, Zhang Q, Shen Y, Cheung A, Wong F, Wong YH, Ip NY, Jiang L, Yung WH, Liu K. Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. Neurobiology of Disease 2015 Jan;73:366-76. Epub 2014 Oct 16.

  13. Liu K, Tedeschi A, Park KK, He Z. Neuronal intrinsic mechanisms of axon regeneration. Annual Review of Neuroscience 2011;34:131-52.

  14. Babiarz J, Kane-Goldsmith N, Basak S, Liu K, Young W, Grumet M. Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture. Experimental Neurology 2011 May;229(1):72-9.

  15. Liu K*, Lu Y*, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neuroscience 2010 Sep;13(9):1075-81.

  16. Park KK, Liu K, Hu Y, Kanter J, He Z. PTEN/mTOR and axon regeneration. Experimental Neurology 2010 May;223(1):45-50.

  17. Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J and Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science 2009 Oct 23;326(5952):592-6.

  18. Park KK*, Liu K*, Hu Y*, Smith PD*, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 2008 Nov 7;322(5903):963-6.

  19. Ji B, Case LC, Liu K, Shao Z, Lee X, Yang Z, Wang J, Tian T, Shulga-Morskaya S, Scott M, He Z, Relton JK, Mi S. Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury. Molecular and Cellular Neuroscience 2008 Oct;39(2):258-67.

  20. Riegger T, Conrad S, Liu K, Schluesener HJ, Adibzahdeh M, Schwab JM. Spinal cord injury-induced immune depression syndrome (SCI-IDS). European Journal of Neuroscience 2007 Mar;25(6):1743-7.

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