Division of Life Science
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PhD Johns Hopkins

Email: jxia@ust.hk


Research Interests

Organization of synapse and regulation of synaptic transmission.

Molecular mechanism of protein trafficking and its implication in diseases.


Ten Selected Publications

  1. He J, Xia M, Yeung PKK, Li J, Li, Z, Chung KK, Chung SK, Xia J* (2018) PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect. PNAS 115(30):E7193-E7201
  2. Wu M, Tian HL, Liu X, Lai JHC, Du S, Xia J* (2018) Impairments of Inhibitory Synapse Formation and Motor Behaviors in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Reports 23:1691-1705.
  3. Xu J, Kam C, Luo J, Xia J*. (2014) PICK1 Mediates Synaptic Recruitment of AMPA Receptors at Neurexin-induced Postsynaptic Sites. J. Neurosci. 34(46):15415-15424
  4. Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KKY, Xu A, Lee KM, Jiang L and Xia J* (2013). PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance. PLOS Biology, 11(4): e1001541.
  5. Xu J, Xiao N, Xia J* (2010). Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nat. Neurosci. 13(1):22-4.
  6. Xiao N, Kam C, Shen C, Jin W, Wang J, Lee KM, Jiang L and Xia J* (2009). PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. J. Clin Invest. 119(4):802-812.
  7. Pan L, Wu H, Shen C, Shi Y, Jin W, Xia J* and Zhang M* (2007). Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. 26(21):4576-87 *Co-corresponding authors.
  8. Jin W, Ge W, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M and Xia J* (2006). Lipid Binding Regulates PICK1’s Synaptic Targeting, AMPA Receptor Trafficking and Synaptic Plasticity. J. Neurosci. 26(9):2380-2390
  9. Xia J, Chung HJ, Wihler C, Huganir RL and Linden DJ (2000). Cerebellar Long-Term Depression Requires PKC Regulated Interactions Between GluR2/3 and PDZ Domain-Containing Proteins. Neuron, 28(2):499-510.
  10. Xia J, Zhang X, Staudinger J, Huganir RL. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22(1):179-87.


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