Division of Life Science
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Zhenguo WU

PhD Western Ontario

Email: bczgwu@ust.hk


Research Interests
Molecular regulation of muscle stem cells, myogenic differentiation, and muscle regeneration.

Representative Publications

  1. Xu, Q., and Wu, Z. (2000). The insulin-like growth gactor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in Rhabdomyosarcoma-derived RD cells. J. Biol. Chem. 275: 36750-36757.
  2. Xu, Q., Yu, L., Liu, L.Y., Cheung, C.F., Li, X., Yee, S.P., Yang, X.J., and Wu, Z. (2002). The p38 MAPK, CaMK and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression. Mol. Biol. Cell. 13: 1940-1952.
  3. Chan, J.K.L., Sun, L., Yang, X.-J., Zhu, G., and Wu, Z. (2003). Functional characterization of an amino terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity. J. Biol. Chem. 278: 23515-23521.
  4. Wan, J., Sun, L., Mendoza, J.W., Chui, Y.L., Huang, D.P., Chen, Z.J., Suzuki, N., Suzuki, S., Yeh, W.C., Akira, S., Matsumoto, K., Liu, Z.G., and Wu, Z. (2004). Elucidation of the JNK pathway mediated by Epstein-Barr virus encoded latent membrane protein 1. Mol. Cell Biol. 24: 192-199.
  5. Sun, L., Liu, L., Yang, X.-J., and Wu, Z. (2004). Akt binds Prohibitin 2 and relieves its repression on MyoD and muscle differentiation. J. Cell. Sci. 117: 3021-3029.
  6. Cheung, P.-Y., Zhang, Y., Long, J.F., Lin, S.C., Zhang, M.J., Jiang, Y., and Wu, Z. (2004). p150 Glued, dynein and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs”, J. Biol. Chem. 279: 45308-45311. (Accelerated Publications)
  7. Ma, K., Chan, J.K.L., Zhu, G., and Wu, Z. (2005). Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity and myogenic differentiation. Mol. Cell. Biol. 25: 3575-82.
  8. Wan, J., Zhang, W., Wu, L., Bai, T., Zhang, M., Lo, K.-w., Chui, Y.-l., Cui, Y., Tao, Q., Yamamoto, M., Akira, S. and Wu, Z. (2006). BS69, a specific adaptor in the latent membrane protein 1-mediated cJun N-terminal kinase pathway. Mol. Cell. Biol. 26: 448-456.
  9. Wu, L., Nakano, H. and Wu, Z. (2006). The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kB through TRAF6 and TAK1. J. Biol. Chem. 281: 2162-2169.
  10. Li, Z.Y., Yang, J., Gao, X., Lu, J.Y., Zhang, Y., Wang, K.P., Cheng, M.B., Wu, N.H., Zhang, Y., Wu, Z*., Shen, Y.F*. (2007). Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate induced early differentiation of Rhabdomyosarcoma-derived cells. J. Biol. Chem. 282: 18872-8. (*Co-corresponding author)
  11. Zhang, W., Chan, H.M., Gao, Y., Poon, R. and Wu, Z. (2007). BS69 is involved in cellular senescence through the p53-p21Cip1 pathway. EMBO Reports 8: 952-8.
  12. Sun, L., Ma, K., Wang, H., Xiao, F., Gao, Y., Zhang, W., Wang, K., Gao, X., Ip, N., and Wu, Z. (2007). JAK1/STAT1/STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J. Cell Biol. 179: 129-138.
  13. Wang, H., Xu, Q., Xiao, F., Jiang, Y., Wu, Z. (2008). Involvement of the p38 mitogen-activated protein kinase a, b and g isoforms in myogenic differentiation. Mol. Biol. Cell. 19: 1519-28.
  14. Wang, K., Wang, C., Xiao, F., Wang, H. and Wu, Z. (2008). JAK2/STAT2/STAT3 are required for myogenic differentiation. J. Biol. Chem. 283: 34029-36.
  15. Diao, Y., Wang, X., and Wu, Z.(2009). SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. Mol. Cell. Biol. 29: 5084-93.
  16. Diao, Y., Liu, W., Wong, C., Wang, X., Lee, K., Cheung, P.Y., Pan, L., Xu, T., Han, J., Yates III, JR., Zhang, M., and Wu, Z. (2010). Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase 6 by inhibiting ATP binding. Proc. Natl. Acad. Sci. U S A 107: 20974-9. (Epub 2010 Nov 15)
  17. Xiao, F., Wang, H., Fu, X., Li, Y., Ma, K., Sun, L., Gao, X., and Wu, Z. (2011). Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration. Cell Res. 21: 350-64.
  18. Xiao, F., Wang, H., Fu, X., Li, Y., and Wu, Z. (2012). TRAF6 Promotes Myogenic Differentiation via the TAK1/p38 Mitogen-activated Protein Kinase and Akt Pathways. PLoS ONE 7: e34081.
  19. Diao, Y., Guo, X., Li, Y., Sun, K., Lu, L., Jiang, L., Fu, X., Zhu, H., Sun, H., Wang, H., and Wu, Z. (2012) Pax3/7BP Is a Pax7- and Pax3-Binding Protein that Regulates the Proliferation of Muscle Precursor Cells by an Epigenetic Mechanism. Cell Stem Cell 11:231-41.
  20. Qiqi Sun, Yanfeng Li, Sicong He, Chenghao Situ, Zhenguo Wu, and Jianan Y. Qu (2013). Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development. Biomed. Opt. Express, 5: 158-166.
  21. Diao Y, Guo X, Jiang L, Wang G, Zhang C, Wan J, Jin Y, and Wu Z (2014). miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. J. Biol. Chem. 289: 529-39.
  22. Zhu H, Xiao F, Wang G, Wei X, Jiang L, Chen Y, Zhu L, Wang HX, Diao Y, Wang HT, Ip NY, Cheung TH, and Wu Z (2016). STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. Cell Rep 16: 2102-15.
  23. An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang HT, and Wu Z (2017). A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Dev Cell. 41: 382-91.
  24. Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung TH, Liu K, and Wu Z (2018). p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO J. e98239. (published online 26.03.2018)


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