Sensory information processing, perception, attention, memory, navigation and adaptive motor control
My lab investigates the neural mechanisms that allow animals to represent dynamic sensory information in the natural environment and direct their actions to track moving targets and navigate in 3D space. Our empirical studies exploit a powerful animal model that provides explicit information about the signals it uses to guide behavior through an active sensing system. This animal model, the echolocating bat, coordinates its production of sonar signals with flight maneuvers in response to 3D spatial information, and exhibits a rich display of natural sensory-guided behaviors. We have established methods to collect multi-channel wireless neural recordings from free-flying bats, which allows for the study of brain systems in animals engaged in natural behaviors. Our work aims to develop a broad understanding of complex signal processing in biological systems and to establish an empirical foundation for integrative models of spatial information processing, the perceptual organization of natural stimuli, spatial navigation and adaptive sensorimotor control.
- Kothari, N., Wohlgemuth, M., and Moss, C.F. Dynamic representation of 3D auditory space in the midbrain of the free-flying echolocating bat, eLife, 2018; 7:e29053. DOI: https://doi.org/10.7554/eLife.29053.
- Luo, J., Kothari, N.B. and Moss, C.F. Sensorimotor integration on a rapid time scale. Proceedings of the National Academy of Sciences, 2017, doi:10.1073/pnas.1702671114.
- Wohlgemuth, M. Kothari, N.B., and Moss, C.F. Action enhances acoustic cues for auditory localization in echolocating bats. Public Library of Science Biology, 2016, http://dx.doi.org/10.1371/journal.pbio.1002544.
- Sterbing-D’Angelo, S.J., Chadha, M., Falk, B. Barcelo, J, Zook, J.M. and Moss, C.F. Bat wing sensors support flight control, Proceedings of the National Academy of Sciences, 2011, 108 (27): 11291-11296.
- Ulanovsky, N and Moss, C.F. Hippocampal cellular and network activity in freely-moving echolocating bats, Nature Neuroscience, 2007, 10(2): 224-233.