Prof. Hyokeun Park received his Ph.D. in Chemical Physics at University of Illinois at Urbana-Champaign in 2006. He worked at Stanford University as a postdoctoral fellow until 2013. He became a joint professor in the division of Life Science and department of Physics in 2014. He has worked on single-molecule biophysics and neuroscience. His research focus on the dynamics of single-molecules and synaptic transmission in neurons using new fluorescence microscopy techniques.
Enormous progress in single-molecule fluorescence microscopy has enabled us to directly observe movements and interactions of individual proteins. Using single-molecule fluorescence microscopy techniques, we are working on dynamics of single molecules and organelles to reveal mysteries of nature. A synergy developed among the different majors, including biology, physics and engineering, allow us to study biological questions with the state-of-the-art techniques including real-time three-dimensional nanometer-accuracy tracking setup, fluorescence resonance energy transfer(FRET) and magnetic tweezers. Our main research goals are:
(1) investigating exocytosis and endocytosis of inhibitory synaptic vesicles.
(2) discovering mechanisms of neuronal death in mouse models of neurodegenerative diseases.
(3) exploring the stepping mechanism of myosin X.
(4) investigating non-Gaussian dynamics of membrane proteins.
- Sidong Chen, Chenglong Yu, Li Rong, Chun He Lai, Xianan Qin & Hyokeun Park, Altered synaptic vesicle release and Ca2+ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of Huntington’s disease, Frontiers in Molecular Neuroscience,11:478 (2018)
- Chenglong Yu, Chun Hei Li, Sidong Chen, Xianan Qin & Hyokeun Park. Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease, Scientific Reports, 8, 16976 (2018)
- Adolfo Alsina#, Wu Ming Lai#, Wai Kin Wong#, Xianan Qin, Min Zhang, & Hyokeun Park, Real-time subpixel-accuracy tracking of single mitochondria in neurons reveals heterogeneous mitochondrial motion. Biochemical and Biophysical Research Communications 493 pp. 776-782 (2017) (#-equal contribution)
- Ropar V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar C, Sweeney HL & Houdusse A. The myosin X motor is optimized for movement on actin bundles, Nature Communications, 7, 12456 (2016)
- Park H, Li Y and Tsien RW. Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science 335, 1362-1366 (2012).