Sensory neurobiology: mechanotransduction in hair cells in the inner ear;
Mechanical and chemical regulation of ion channels; and
My research interest is mainly focused on mechanical and chemical regulation of ion channels. Recently, my lab is particularly interested in understanding the molecular mechanism of mechanotransduction in hair cells in the inner ear, one of the key questions in sensory neurobiology. We employ a multidisciplinary approach that harnesses the power of cutting-edge techniques in molecular biology, cell biology, and biophysics.
Yu X, Zhao Q, Li X, Chen Y, Tian Y, Liu S, Xiong W, and Huang P. Deafness mutation D572N of TMC1 destabilizes TMC1 expression by disrupting LHFPL5 binding. PNAS, in press, 2020
Li X, Yu X, Chen X, Liu Z, Wang G, Li C, Wong EYM, Sham, MH, Tang J, He J, Xiong W, Liu Z, and Huang P. Localization of TMC1 and TMHS in auditory hair cells in neonatal and adult mice. FASEB Journal, 33 (6), 6838, 2019.
Hu W*, Yu X*, Liu Z*, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, and Huang P. The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. eLife, 6, e28021, 2017.
Xie C, Cao X, Chen X, Dong Wang, Zhang WK, Sun Y, Hu W, Zhou Z, Wang Y, and Huang P. Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia. The FASEB Journal, 30(4), 1579-89, 2016, (Recommended by Faculty1000 Prime).
Zhang WK, Wang D, Duan Y, Loy MMT, Chan HC, and Huang P. Mechanosensitive gating of CFTR. NatureCell Biology, 12(5): 507-12, 2010