Dr. Yan received a B.S. degree in Peking University in 2004 and a Ph.D. degree in Molecular Biology from Princeton University in 2010.
Our laboratory is interested in using quantitative approaches to understand how cell structural components are orchestrated to regulate tissue morphogenesis and growth.
Tiantian Ji1,2*, Lina Zhang1,2*, Mingxi Deng1,2, Shengshuo Huang1,2,3, Ying Wang1,2, Tri Thanh Pham4, Andrew Alan Smith4, Varun Sridhar4, Clemens Cabernard4, Jiguang Wang1,2,3, Yan Yan1,2, Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors. (Under review) An early version of preprint available in https://doi.org/10.1101/450486
Mingxi Deng1,2, Lina Zhang1,2, Ying Wang1,2, Shengshuo Huang1,2,3, Jiguang Wang1,2,3, Hao Ge4, Yan Yan1,2, Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs. (Under review)
Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts, Yanru An, Guosheng Xue, Yang Shaobo, Deng Mingxi, Xiaowei Zhou, Weichuan Yu, Toyotaka Ishibashi, Lei Zhang, Yan Yan, Development, 2017 June, Highlighted in Editor’s Choice, “A new model for single-cell delamination”
Kenneth Kin Lam Wong, Wenyang Li, Yanru An, Yangyang Duan, Yibin Kang, Yan Yan, β-Spectrin regulates the Hippo signaling pathway and modulates the basal actin network, J Biol Chem, 2015 Mar.
Yan Yan*, Natalie Denef*, Trudi Schupbach, The vacuolar proton pump, V-ATPase, is required for Notch signaling and endosomal trafficking in Drosophila. Dev Cell. 2009 Sep *These authors contribute equally to this work.